Patients were included if they had an ICD-10 code for gram-negative pneumonia and receipt of cefiderocol or meropenem after pneumonia diagnosis, defined by RxNorm codes. Antibiotic receipt after pneumonia diagnosis defined the index event date. Patient cohorts were balanced using demographic (age, ...
31 Automated antibiograms can incorporate chronic medical conditions to guide empiric therapies that are better targeted to patients with risk factors for infection with antimicrobial-resistant organisms. For example, criteria using ICD-10 coding and previous clinical encounters can group medically complex...
Tobramycin (2.5 mg/ml) and 10 mM PBS (pH 7.0) served as positive controls in the same e-plate whereas Triton X100 served as a negative control. Culture was maintained for 96 hours with no media change. CI values of treated groups were normalized once the values stabilized after ...
Spinal Cord Injury Increases the Risk of Gram-Negative BacteremiaIndividuals with spinal cord injury (SCI) have a lifelong increased risk of systemic infection, including bacteremia. Although gram-positive pathogens are, in general, the most common cause of nosocomial bloodstream infections, we ...
While most cases are exogenous, gram negative (GN) EO account for 10-24% of all cases, and endogenous EO (EEO) account for 2-8% of all cases. Risk factors for EEO include diabetes mellitus (DM), IV drug use, and indwelling catheters. Major sources of infection are urinary tract ...
Anthony Harris, MD, MPH, Innoviva: Advisor/Consultant|UpToDate: Infection Control Editor Kimberly C. Claeys, PharmD, PhD, bioM茅rieux: Advisor/Consultant|bioM茅rieux: HonorariaHarris AnthonyGoodman Katherine EPineles LisaWalker MorganBork Jacqueline T...
Secondary outcomes consisted of 30 day infection related hospital readmission, length of stay, Clostridioides difficile infections, total active days of therapy, and development of resistance. Patients were matched in a 1:1 ratio based on type of GNB (Enterobacterales vs non-Enterobacterales), age...
sta Keywords: colonization;infection;rectal swab;Acinetobacter;Klebsiella;Enterobacteriaceae;carbapenem;carbapenem-resistant Gram-negative bacteria;polytrauma;trauma;ICU
Gram-negative bacteria are ubiquitous in nature and cause infection in multiple body sites including the urinary tract, lower respiratory tract, biliary tract, and bloodstream, among others. Due in large part to the selective pressure of antibiotic use, resistance has significantly increased in gram-...
Vaara, M. Polymyxin derivatives that sensitize Gram-negative bacteria to other antibiotics. Molecules 2019, 24, 249. [CrossRef] 11. Vaara, M. New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin. Med. Res. Rev. 2018, 38,...