Background: Immunohistochemical analysis of biomarkers is essential to understand the nature of breast cancer (BC) and predict its prognosis. A noticeable correlation is found between p53-positive and transforming growth factor-beta receptor 2 (TGFBR-2)-negative immunomarker expression in BC cases. ...
lymph node spread, cell type and tumor grade and the presence or absence of metastasis. In some type of cancers, other factors are also considered forstaging, like ulceration status or tumor thickness in melanoma;stagingof cancers of the brain according to the cell type and grade. ...
Breast carcinoma grading is an important prognostic feature recently incorporated into the AJCC Cancer Staging Manual. There is increased interest in applying virtual microscopy (VM) using digital whole slide imaging (WSI) more broadly. Little is known regarding concordance in grading using VM and how...
Staging of cancer describes the size and/or extent (reach) of the original (primary) tumor and whethercancer cellshave spread in the body. The cancer stage is based on factors such as the location of theprimary tumor, tumor size, regional lymph node involvement (the spread of cancer to the...
Aims: To assess the validity of grading in the Edinburgh Breast Conservation Series; a consecutive cohort of 1812 early breast cancer patients treated by breast conservation and radiotherapy between 1981 and 1998 in a single specialist centre with ≥9 years' follow-up and full staging data.关...
Slideshow Pancreatic Cancer: Difficult Diagnosis, Ominous Outlook Initial Evaluation Grading and Staging Gastrointestinal and Pulmonary Carcinoid Tumors Neuroendocrine Tumors of the Pancreas Pheochromocytoma Adrenal Carcinomas and Incidentalomas Questions & Answers Show All ReferencesRecommended...
The Gleason grading system remains the most powerful prognostic predictor for patients with prostate cancer since the 1960s. Its application requires highly-trained pathologists, is tedious and yet suffers from limited inter-pathologist reproducibility, especially for the intermediate Gleason score 7. Autom...
The Scarff-Bloom-Richardson (SBR) grade, an important prognostic factor in breast cancer, was also associated with cell proliferation, a consistent indicator of response to chemotherapy. The determination of an association between SBR grade and responsiveness would be clinically useful. We explored the...
Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer breast cancer, and ERBB2 seems to be one of the factors shifting balances of both factors of the redox control system in a prognostic unfavorable manner... C Cadenas,D Franckenstein,M Schmidt… -...
The histological grading of colorectal cancer is not only a reference basis for assessing its malignancy and staging, but also an important factor affecting its prognosis4. Histopathological image analysis is the gold standard for pathologists to grade colorectal cancers of different differentiation types...