The survival rate of glioblastoma (GBM) is even worse, with only about a quarter of patients surviving two years after diagnosis and only 5% to 14% living beyond five years3,4,5 Current treatment strategies include maximal tumour resection combined with radiotherapy and temozolomide chemotherapy. ...
In our current study, tumor BRCA1/2 deleterious variants were identified in 31.2% of HGOCs, one quarter of these mutations are somatic. This rate is in line with previously reported rates of 18%–24% in the Chinese population. Improved prognosis with higher partial response (PR) and ...