Health-related quality of life and cognitive functioning in long-term anaplastic oligodendro‑ glioma and oligoastrocytoma survivors. J Neuro-Oncol. 2014;116:161–8. 11. Lassman AB, Iwamoto FM, Cloughesy TF, Delgadillo D, Hoang-Xuan K, et al. International retrospective study of over ...
Glioblastoma (GBM), defined as an isocitrate dehydrogenase (IDH)-wildtype World Health Organization (WHO) grade 4 astrocytoma, is the most aggressive type having the worst prognosis of HGGs. Despite intensive SOC treatment, tumor recurrence is inevitable and remains uniformly lethal with no current...
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial Lancet Oncol, 13 (2012), pp. 707-715 View in ScopusGoogle Scholar 21. W. Wick, C. Meisner, B. Hentschel, et al. Prognostic or predictive value of MGMT ...
High-grade gliomas (HGG) are solid malignant tumours that arise from the uncontrolled differentiation of astrocytes and may be classified as grade III anaplastic astrocytoma, oligodendroglioma, or oligoastrocytoma, along with grade IV glioblastoma multiforme. HGGs account for the majority of primary brai...
The methylation status of the promoter of the gene that codes for the MGMT protein was searched by polymerase chain reaction (PCR) in 18 patients, finding methylation in 3/10 glioblastomas (30%), 2/3 anaplastic astrocytoma (66%), and 4/4 tumors of the oligodendroglial lineage (100%) (...
The pathological diagnosis was anaplastic oligoastrocytoma (grade 3, MGMT unmethylated, IDH mutant and no 1p19q codeletion). However, her tumor recurred and could not be removed as it was located in a functional area (Figure 2a). She was thus enrolled in our study. Her tumor decreased in...
Gr4 adult-type diffuse glioma, including IDH-mutant gr4 astrocytoma and IDH-wt GBM gr4, represents a significant entity within CNS tumors and remains a highly fatal disease with a median survival expectancy of only 9–15 months despite ongoing clinical research endeavors [2,3]. Its aggressive...