MucositisPancytopeniaALLAntimetabolite drugs are rarely associated with grade 3 or 4 mucositis. However specific side effects such as bone marrow suppression, pancytopenia, hospitalization, high cost limit the use of intravenous methotrexate. Here we report a case of 25-year-old girl patient with ...
Of note, 2 grade 3 cases of mucositis and neutropenia were observed and a grade 4 elevation of liver enzymes was seen in another case, with 2 patients dying due to disease progression during treatment. Still, daily use of this drug provided physicians with an alternative treatment for patient...
Several oral agents targeting MEK1/2 have been studied in pLGG, in both biomarker-selected and unselected populations. In the 2010s, early phase evaluations of MEK inhibitors began based on the finding that the majority of pLGGs harbor an activation of the RAS/MAPK pathway through various ...
the incidence of grade 2 or higher adverse events, including nausea and vomiting, dermopathy, pain, oral mucositis, diarrhea and dysgeusia, tended to be... H Fujii,Y Ueda,C Hirose,... - 《Journal of Pharmaceutical Health Care & Sciences》 被引量: 0发表: 2022年 Phase I study of mirvet...
Oral mucositis 45 (35%) 34 (27%) 8 (6%) 3 (2%) 23 (18%) 13 (10%) 8 (6%) 2 (2%) Nausea 78 (61%) 43 (34%) 23 (18%) 12 (9%) 65 (51%) 39 (31%) 12 (9%) 14 (11%) Vomiting 59 (46%) 40 (31%) 10 (8%) 10 (7%) 44 (35%) 24 (19%) 10 (8%) 10 ...
Two-year OS was 30% and PFS was 20% and 27% of the patients had no evi- dence of recurrent disease at 2 years. Mucositis and oral pain were the most common grade 3 adverse events, fol- lowed by fatigue, bone necrosis in 3 patients and soft tis- sue necrosis in one. Based on ...
Abstract 30: The development of a 3D cell-culture model of drug-induced oral mucositis Purpose: Mucositis is a debilitating disease affecting cancer patients. Mucositis is an adverse effect of radiation or chemotherapy. In the past, our lab h... Maria P. Lambros,QinQin Fei,Jonathan Moreno - ...
Topical dexamethasone rinses or topical corticosteroids may be employed for commonly seen mucositis and stomatitis [37]. Additionally, episodes of interstitial pneumonitis have been documented to easily resolve with the use of oral steroids [25]. Other side effects may be managed supportively, including...
Relationship between the maximum point dose in the oral mucosal dose surface model and acute radiation mucositis (ARM) grade (Common Terminology Criteria for Adverse Events [CTCAE] classification).Atsushi, ...
Grade 1 and 2 toxicities predominated; two definitively related grade 3 toxicities (mucositis and neutropenia) occurred. Grade 4 elevation of liver enzymes was possibly related in one patient. Predose blood levels showed substantial variability between patients with 45.5% below and 18.2% above the ...