MucositisPancytopeniaALLAntimetabolite drugs are rarely associated with grade 3 or 4 mucositis. However specific side effects such as bone marrow suppression, pancytopenia, hospitalization, high cost limit the use of intravenous methotrexate. Here we report a case of 25-year-old girl patient with ...
Several oral agents targeting MEK1/2 have been studied in pLGG, in both biomarker-selected and unselected populations. In the 2010s, early phase evaluations of MEK inhibitors began based on the finding that the majority of pLGGs harbor an activation of the RAS/MAPK pathway through various ...
the incidence of grade 2 or higher adverse events, including nausea and vomiting, dermopathy, pain, oral mucositis, diarrhea and dysgeusia, tended to be... H Fujii,Y Ueda,C Hirose,... - 《Journal of Pharmaceutical Health Care & Sciences》 被引量: 0发表: 2022年 Phase I study of mirvet...
Oral mucositis 45 (35%) 34 (27%) 8 (6%) 3 (2%) 23 (18%) 13 (10%) 8 (6%) 2 (2%) Nausea 78 (61%) 43 (34%) 23 (18%) 12 (9%) 65 (51%) 39 (31%) 12 (9%) 14 (11%) Vomiting 59 (46%) 40 (31%) 10 (8%) 10 (7%) 44 (35%) 24 (19%) 10 (8%) 10 ...
Two-year OS was 30% and PFS was 20% and 27% of the patients had no evi- dence of recurrent disease at 2 years. Mucositis and oral pain were the most common grade 3 adverse events, fol- lowed by fatigue, bone necrosis in 3 patients and soft tis- sue necrosis in one. Based on ...
Abstract 30: The development of a 3D cell-culture model of drug-induced oral mucositis Purpose: Mucositis is a debilitating disease affecting cancer patients. Mucositis is an adverse effect of radiation or chemotherapy. In the past, our lab h... Maria P. Lambros,QinQin Fei,Jonathan Moreno - ...
2. Patient information A 56 years old male patient was diagnosed with carcinoma of left breast in July 2010. Five years before cancer diagnosis, he had multiple injuries on chest wall and back; and had fractured left hand. He had heredity of cancer, paternal uncle suffering from hepatocellular...
Relationship between the maximum point dose in the oral mucosal dose surface model and acute radiation mucositis (ARM) grade (Common Terminology Criteria for Adverse Events [CTCAE] classification).Atsushi, ...
Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due to high doses of chemotherapy and/or radiotherapy. The purpose of this investigation was to perform a comparative study of the frequency and evolution of OM among patients subjected to ...
Oral Dis. 2007;13:170 -176.Bonan PRF, Kaminagakura E, Pires FR, Vargas PA, De Almeida OP. Histomorphometry and immuno- histochemical features of grade I (WHO) oral radiomucositis. Oral Dis 2007; 2:170-6. http://dx.doi.org/ 10.1111/j.1601-0825.2006.01254.x...