In conclusion, behavior and prognosis of WHO grade 2 and 3 glioma were unfavorable in correlation to patient's age, even if the extent of resection was comparable. Older age imparted a poorer PFS and higher CE rate only in the IDH wild-type population....
Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly to current therapies. Here we report a completed phase I trial evaluating IL-13Rα2-targ
Caring for someone with high-grade glioma: a time of rapid change for caregivers Patients diagnosed with high-grade gliomas have a poor prognosis and limited life expectancy, and often experience rapid decline in function. Caring for a ... McConigley, R.,G Halkett,E Lobb,... - 《...
Histopathological evaluation of tumor tissue remains the standard method for diagnosis and classification of glioma (Fig. 2), but diagnostic challenges are well recognized, including subjective criteria, tissue sampling error, and lack of specific tumor markers [16, 18–24]. In general, lesions detec...
assessed the cognitive function of patients with low-grade glioma who had an average follow-up of 7.4 years. A limited number of patients in the study showed signs of impaired cognitive function after undergoing radiotherapy. However, the decline in cognitive function was not apparent with the ...
doi:10.1007/978-1-4419-6306-2_5Michele R LucasAdvances in Experimental Medicine and BiologyLucas MR. The impact of chemo brain on the patient with a high-grade glioma. Adv Exp Med Biol 2010; 678: 21-25.Lucas MR (2010) The impact of chemo brain on the patient with a high-grade ...
astrocytoma; glioblastoma; end of life; supportive care; palliative care; high-grade glioma1. Introduction Primary brain tumors represent about 2% of the overall cancer diagnoses, and more than 75% of them are high-grade gliomas (HGGs) [1,2,3]. HGG is still nowadays an incurable disease, ...
Patients suffering from diffuse Low-Grade Glioma (LGG) are usually young adults and present long life expectancy thanks to multimodal therapeutic management. In this context, the preservation of quality of life (QoL) is essential, and sexual health is part of it. We reviewed here the current kn...
In grade 4 gliomas, the incidence of its mutation can be found in up to 70% of cases, and its absence leads to the activation of the gliomagenesis process by activating the Rb1 pathway [39]. The presence of deletion is more common in IDH-mutant astrocytomas (approximately 34% of cases...
vaccine therapy; oncoantigen; tumor associate antigen; tumor angiogenesis; high-grade glioma1. Introduction High-grade gliomas (HGGs) carry a dismal prognosis despite current treatments [1,2,3,4]. Options are particularly limited for patients with recurrent HGGs so new therapies are needed. ...