CRP associated CpGs in genomic and biological context Next, we evaluated if the CpG methylation signature was enriched within certain genomic features. We performed an overrepresentation analysis that mimicked the DNA methylation variation structure of our 1511 loci (“Methods”). We compared the geno...
In terms of inflammatory mediators, super-low-dose LPS caused significant elevation of pro-inflammatory cytokines such as tumour necrosis factor-a and interleukin (IL)-6, as well as chemokine MCP-1 (Fig. 2d–g). Given the elevated levels of MCP-1, we further tested whether there were ...
James Watson, the author of The Double Helix, later told her it was the most important biological advance: since he and Francis Crick discovered the structure of DNA. For this achievement, Doudna and Charpentier were awarded the Nobel Prize in Chemistry in 2020. Until now, only five women, ...
Common Terminology Criteria for Adverse Events (CTCAE) [https://nciterms.nci.nih.gov/ncitbrowser/pages/vocabulary.jsf?dictionary=CTCAE_v5&version=5.0]. Elgaz S, Kuci Z, Kuci S, Bonig H, Bader P. Clinical use of mesenchymal stromal cells in the treatment of acute graft-versus-host disease...
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They did not consider the results in terms of objective response rate to be dramatic and the validity as a surrogate endpoint for clinical benefit had not been established. Additionally, the results presented in terms of OS and PFS were difficult to interpret owing to the lack of a randomized...
[26]. We dichotomized patients in high or low mRNA levels of ETAR, ILK, YAP, AP-1, or ZEB1 alone or in combination and found that patients who expressed high mRNA levels of a broader integrated ETAR/ILK/YAP/AP-1/ZEB1 signature exhibited worsening prognosis in terms of overall survival ...
A direct comparison of the CV of each method was not possible because replicate analyses of the samples were not conducted; therefore, a CV-like score was calculated, which represents the biological variability of the sibling peptides from the quantified proteins. Because aliquots of identical ...
GSVA (gene set variation analysis) was implemented for the function annotation of distinct subgroups by using the GSVA package in R software47. The differentially enriched molecular mechanisms including Gene Ontology (GO) molecular function terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathw...
or quantification of reactive stroma, were also beyond the scope of this study. Adding extensive molecular profiling and computational pathology in the future will not only potentially improve the performance of the model, but also enable detailed biological interpretation of the main drivers behind res...