Women are particularly susceptible to OA, accounting for approximately 60% of all OA patients3. Age is a major risk factor, with the prevalence in women escalating from approximately 10% at ages 25–34 to over 50% at ages 75 and older2. Exercise plays a pivotal role in sustaining overall...
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However, the disialoganglioside GD2 is present in several tumor types, including GBM101,102, while its expression in normal tissue is primarily limited to the CNS and peripheral nerve tissues, accounting for less than 4% of all gangliosides103,104,105. In preclinical trials, GD2-targeting CAR-...
Specifically, high-grade serous ovarian carcinoma (HGSOC) is the most common subtype of EOC accounting for almost 75% of all EOCs. Unfortunately, the majority of patients are diagnosed as advanced stage III-IV at the time of preliminary diagnosis [5,6,7]. Historically, standard treatments for...
2,3,4 In China, 47,739 deaths and 106,430 new cases of CC have been recorded, accounting for 18.7% of diagnoses and 15.3% of deaths globally.5 CC screening programs can lower the incidence of CC6; however, the incidence rates are still high in low-/middle-income countries.7 It is ...
Article Open access 19 January 2023 Introduction Stroke has increased the economic burden imposed on health care systems, accounting for 2% to 4% of total health care costs1 and is a major cause of death and permanent disability worldwide2. More than half of the patients who suffer from str...
Low-grade gliomas (LGGs) are the most common type of brain tumors in children and adolescents, accounting for almost 30–40% [1,2]. Despite an excellent prognosis with a 20-year overall survival (OS) exceeding 87% [3,4], patients with pediatric LGGs (pLGGs) frequently relapse or progr...
Figure 9 shows 139 and 161 high-grade tourist attractions in 10 km and 20 km buffer zones, accounting for 56.28% and 65.18% of the total number, further indicating that traffic development influences the spatial distribution of tourist attractions. From the result, 3A-grade tourist attractions ...
The concept of drug–tumor residence time avoids the limitations of in vitro assays that measure equilibrium binding metrics and drug-binding affinity and refers to the lifetime of the binary drug–target complex in vivo accounting for absorption, metabolism, and tissue distribution [52]. Further...
Colorectal cancer is the third most frequently diagnosed cancer, accounting for approximately 10% of all cancer incidences and standing as the world’s second primary cause of death due to cancer [1]. Rectal cancer presents a major health challenge because of its high incidence and mortality rate...