食欲素(Orexin)通过受体特异性地和G蛋白Gq偶联,激活不同的G蛋白相关信号通路,参与学习记忆过程.其中,Gq蛋白/磷脂酶c/蛋白激酶c(Gq/PLC/PKC)是Orexin-A的关键信号通路.睡眠剥夺可提高脑内Orexin-A水平,引起海马神经细胞损害,导致学习记忆功能减退.特异性阻断和调控这一信号通路上的某一靶点,既能改善睡眠,又能逆转...
GqPKCERK糖尿病(Diabetes)是困扰人们的主要疾病之一,因其多发性和危害性受到高度重视.黄连素(Berberine,BBR)是一种从黄连等植物中提取的化合物,有很好的抗菌,抗炎症,抗肿瘤作用.但其治疗糖尿病的作用一直被忽视.最近G蛋白偶联受体GPR40已被确定为是黄连素的受体.然而,黄连素作为GPR40的配体的信号通路还没有被系统的...
(2016) Agonist-mediated activation of Bombyx mori diapause hormone receptor signals to extracellular signal-regulated kinases 1 and 2 through Gq-PLC-PKC-... Q Jing,Y Gu,C Wu,... - 《Cellular & Molecular Biology Letters》 被引量: 5发表: 2017年 Effects of ecdysteroid agonist RH-5849 on pu...
Moreover, chemical inhibitors against Gq, PLC or PKC blocked kisspeptin-induced glioblastoma cell invasiveness. Conclusion: Kisspeptin induces glioblastoma cell invasiveness via the KISS1R-Gq-PLC-PKC signaling pathway.Kim, Tae-HunYoon, Ji HyeCho, Sung-Gook...
Gq-PLC-PKCJNKP38Background: To investigate the mechanism of Xuefu Zhuyu decoction in the treatment of diabetes mellitus erectile dysfunction. Methods: Rats with diabetes mellitus erectile dysfunction were developed using streptozocin and randomly assigned into model, low-dose herbal, and high-dose ...
they did in the model group.Conclusion:Xuefu Zhuyu decoction can decrease injury to the endothelium,improve vascular endothelial diastolic and contractive function,and inhibit vascular fibrosis in rats with diabetes mellitus erectile dysfunction.This mechanism may be related to the CaSR/Gq-PLC-P...