Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking. Biol Psychiatry 78(7): 441-451.Scofield MD, Boger HA, Smith RJ, Li H, Haydon PG, Kalivas PW. 2015. Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking....
将CAG-LSL-HA-GiDREADD(hM3Dq)-P2A-mCitrine-WPRE-polyA插入到小鼠Rosa26基因中。 应用领域:属于化学遗传学元件,用于神经科学研究,药物(叠氮平-N-氧化物,CNO)诱导后GqDREADD(hM3Dq)可刺激神经元的活性。但在不同细胞类型中,诱导效果不一样。 *使用本品系发表的文献需注明: R26-CAG-LSL-GqDREADD(hM3Dq)-...
These studies represent the first use of the pharmacogenetics DREADD technology in the kidney; and demonstrate that selective activation of the P2Y 2 receptor and Gq signaling in principal cells is sufficient to promote renal salt excretion. Support or Funding Information This research was supported ...
We here use DREADD technology to understand the role of Gq-coupled signaling in vivo in cardiac function.We generated a novel transgenic mouse line that expresses a Gq-coupled DREADD (Dq) in striated muscle under the control of the MCK promotor. In vivo injection of the DREADD agonist CNO ...
将CAG-LSL-HA-GiDREADD(hM3Dq)-P2A-mCitrine-WPRE-polyA插入到小鼠Rosa26基因中。 应用领域:属于化学遗传学元件,用于神经科学研究,药物(叠氮平-N-氧化物,CNO)诱导后GqDREADD(hM3Dq)可刺激神经元的活性。但在不同细胞类型中,诱导效果不一样。 *使用本品系发表的文献需注明: R26-CAG-LSL-GqDREADD(hM3Dq)-...
In the present study, we performed a side-by-side evaluation of the effects of bath application of the DREADD agonist, clozapine-N-oxide (10M), on Gq- and Gi-DREADD activation in mouse CA1 hippocampal astrocytes. In doing so, we aimed to avoid confounding factors, such as differences in...
Here, we aimed at determining the role of sex differences in the behavioral and functional outcomes of the chemogenetic activation of spinal microglia using Gq-designer receptors exclusively activated by designer drugs (Gq-DREADD) driven by the microglia-specific Cx3cr1 promoter. CAG-LSL-human Gq...
Using DREADD to Examine the Role of Infralimbic Gq-coupled Receptors in Fear AcquisitionMartínez, Héctor A. HaddockPorter, JamesHernández-López, AnixaJournal of Health Disparities Research & Practice