Gpx4 基因曾用名 GPx-4; PHGPx; snGPx; GSHPx-4; mtPHGPx NCBI ID 625249 MGI ID 104767 Ensembl ID ENSMUSG00000075706 Pubmed Gpx4 人类同源基因 GPX4 品系描述 通过敲除Gpx4基因exon 2-4,建立Gpx4基因敲除小鼠模型。 *使用本品系发表的文献需注明: Gpx4-KO mice (Cat. NO. NM-KO-233589) were purchase...
Gpx4 基因曾用名 GPx-4; PHGPx; snGPx; GSHPx-4; mtPHGPx NCBI ID 625249 MGI ID 104767 Ensembl ID ENSMUSG00000075706 Pubmed Gpx4 人类同源基因 GPX4 品系描述 通过敲除Gpx4基因exon 2-4,建立Gpx4基因敲除小鼠模型。 *使用本品系发表的文献需注明: Gpx4-KO mice (Cat. NO. NM-KO-233589) were purchase...
In Vivo: Lens-specific Gpx4 deletion was achieved using MLR10-Cre/Gpx4f/f, resulting in the observation of cataracts in mice at P0. These cataracts progressively worsened during postnatal lens development, eventually leading to microphthalmia in adult Gpx4 KO mice. Cell death was evident in the...
A combination of ferroptosis inducers and HSF1 inhibitors resulted in tumor growth arrest in mice. That provided a new idea for treating ferroptosis-resistant tumors [76]. SREBP1-SCD1-MUFA PATHWAY Ferroptosis is characterized by lipid peroxidation, so the type of fatty acid can significantly ...
To further validate that 2-BP and ML349 modulate ferroptosis sensitivity by targeting GPX4, we generated GPX4-knockout A375 cells and then injected these cells subcutaneously into nude mice for xenograft assays. The A375 GPX4-KO xenograft tumors were then treated with IKE alone, or in combinatio...
In studies by Wei et al., exogenous irisin was found to inhibit ferroptosis in the livers of septic mice and restore mitochondrial function, with the expression of GPX4 being key; the knockdown of GPX4 negated the protective effects of irisin. These findings affirm the substantial potential of ...
mice. Scale bar, 100 μm. Data are the mean ± s.d.g-k, Wild-type or R152 mutant Flag-GPX4 were transinfected into GPX4-knockdown C4-2 cells, then cells were subjected to mouse xenograft assays. When the tumor reached 50 mm3, the mice were assigned randomly into different treatment ...
MSDS ¥2200/100 μL Cat No.67763-1-Ig 浓度:1000 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 mouseWB View Article human,mouseWB Nucleic Acids Res MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongatio...
a, GPX4 protein expression in splenic CD4+ cells from Cd4-CreNegGpx4flox/flox (WT) and Cd4-CreGpx4flox/flox (T-KO) mice were analysed by flow cytometry (n = 5). b, c, Naïve CD4+ T cells were purified from WT and T-KO mice and cultured in 2-Mercaptoethanol-deprived culture...
To evaluate the pluripotency of the generated mESC lines, wild-type and GPX4-overexpressing naïve mESCs were subcutaneously injected into immunodeficient Balb/c-nu mice to induce teratoma formation. After a defined period, the teratomas were excised, fixed, and subjected to histological analysis. ...