Here, we discuss the roles of classical GPX4 functions as well as emerging GPX4-regulated processes in cell death, autophagy, and disease.Abbreviations: AA: arachidonic acid; cGPX4: cytosolic GPX4; CMA: chaperon
Tubular cell death is the major early event during the process of AKI, which is accompanied by inflammation due to chemokines and damage-associated molecular patterns from the dead and dying cells5. Distinct forms of cell death have been indicated to participate in the loss of tubular cells in ...
possessing a conserved structural arrangement of the RING domain, the B-box domain and the coiled-coil motif at the N-terminus [10], which is involved in multiple biological processes, including innate immunity [11], cell proliferation [12], and the inflammatory response [13]. As...
2. GPX4 and ferroptosis In previous investigations, various types of cell death have been identified and defined based on their distinct morphological features, biomarkers, or regulatory mechanisms, including apoptosis, necrosis, pyroptosis, and autophagy-dependent cell death[29], [30], [31], [32]...
Conjugated fatty acids (CFAs) have been known for their anti-tumor activity. However, the mechanism of action remains unclear. Here, we identify CFAs as inducers of glutathione peroxidase 4 (GPX4) degradation through chaperone-mediated autophagy (CMA). C
MTT assay was performed to quantify cell survival as indicated in a heatmap (n = 3). (B) Schematic diagrams of apoptosis, autophagy, necroptosis, cuproptosis, and ferroptosis. Inhibitors targeting the relative cell death pathways are marked in red colors. (C, D) Superoxide anions in the ...
ApoptosisAutophagyc-KitFerroptosisFLTPDGFRRafVEGFR ¥ 153 现货 规格 数量 客户已引用 Rosiglitazone 罗格列酮, BRL49653 T0334122320-73-4 Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂,具有口服活性。Rosiglitazone 也是一种降糖剂,是噻唑烷二酮类胰岛素增敏剂。
Vitamin D-VDR (vitamin D receptor) regulates defective autophagy in renal tubular epithelial cell in streptozotocin-induced diabetic mice via the AMPK pathway [J]. Autophagy, 2022, 18 (4): 877-890....
虾青素通过调控Nrf2/Gpx4信号通路抑制铁死亡减轻糖尿病小鼠视网膜损伤 张景正,叶子昊,祝可欣,陈灵,鲍真真,钟嫄,刘嘉 Astaxanthin Reduces Retinal Damage in Diabetes Mice by Inhibiting Iron Death through Regulating Nrf2/Gpx4 Signaling Pathway ZHANG Jingzheng, YE Zihao, ZHU Kexin, CHEN Ling, BAO Zhenzhen, ...
A diethylnitrosamine (DEN)-induced HCC model in rats was established and used to evaluate the anti-cancer efficacy of PZH. After detecting a transcriptomic profiling, the “disease-related gene–drug effective target” interaction network was constructed, and the candidate targets of PZH against mali...