In vitro evaluation of glutathione peroxidase (GPx)-like activityand antioxidant properties of an organoselenium compoundMohammad Ibrahima,b, ⇑ , Niaz Muhammad a , Muhammad Naeem a , Anna Maria Deobald c ,Jean Paul Kamdemb , Joao Batista Teixeira Rocha b, ⇑a Department of Chemistry, Abdul...
A significant enhancement in GPx-like enzymatic activity was observed for both novel bioconjugates SeC-Biotin (1) and SeC-Lipoic acid (2) as compared to diphenyl diselenide (Ph2Se2), L-selenocystine (SeC), biotin, lipoic acid, and ebselen.Maurya, Shakti K....
Thiols oxidation for the evaluation of Gpx-like activity. Phosphorus, Sulfur Silicon Relat. Elem 188:507-508; 2013.Santi C, Galli F, Piroddi M, Tidei C. Thiols Oxidation for the Evaluation of Gpx-Like Activity. Phosphorus Sulfur Silicon Relat Elem. 2013;188:507-8....
The factors that are responsible for the relatively low glutathione peroxidase (GPx)-like antioxidant activity of organoselenium compounds such as ebselen (1, 2-phenyl-1,2-benzisoselenazol-3(2H)-one) in the reduction of hydroperoxides with aromatic thiols such as benzenethiol and 4-methylbenzene...
The Selenoenzyme Phospholipid Hydroperoxide Glutathione Peroxidase Controls the Activity of the 15-Lipoxygenase with Complex Substrates and Preserves the S... Mammalian 15-lipoxygenases have been suggested to be involved in cell differentiation and atherogenesis because of their capability of oxygenating poly...
Acidic conditions enhanced their catalytic activity, whereas basic conditions suppressed it. The highest activity was observed with a 2,7-bis(triethyleneglycol) derivative. These compounds serve as mimetics of the antioxidant selenoenzyme glutathione peroxidase. Studies based on NMR peak-broadening effects...
In this paper, we discuss the role of oxo and peroxido species in the GPx activity of V 2 O 5 and MoO 3 . A detailed mechanistic study reveals that the GPx activity of these materials depends on the reactivity of oxo moiety on the surface of the material with H 2 O 2 to form ...
An Update on "Selenium Containing Compounds from Poison to Drug Candidates: A Review on the GPx-like Activity". Curr. Chem. Biol. 2015, 9, 97-112. [CrossRef]Pacuła, A.J.; Mangiavacchi, F.; Sancineto, L.; Lenardao, E.J.; Ścianowski, J.; Santi, C. Selenium Containing ...
Pacuła, A.J.; Mangiavacchi, F.; Sancineto, L.; Lenardao, E.J.; S´cianowski, J.; Santi, C. An Update on "Selenium Containing Compounds from Poison to Drug Candidates: A Review on the GPx-like Activity". Curr. Chem. Biol. 2016, 9, 97-112. [CrossRef]...
Alberto EE, Soares LC, Sudati JH, Borges ACA, Rocha JBT, Braga AL (2009) Efficient synthesis of modular amino acid derivatives containing selenium with pronounced GPx like activity. Eur J Org Chem 4211–4214ALBERTO, E.E.; SOARES, L.C.; SUDATI, J.H.; BORGES, A.C.; ROCHA, J.B.T...