To evaluate the expression of NLRP3 and GPR43 and the release of IL-1尾, human THP-1 cells were stimulated with or without SCFAs (acetate, propionate, and butyrate), lipopolysaccharide (LPS), and nigericin in vitro, respectively. Results: Compared to the controls, the mRNA expression in ...
This result indicates that acetate protects mice from NLRP3 inflammasome-dependent peritonitis and lipopolysaccharide (LPS)-induced endotoxemia. The acetate-GPR43 axis induces colonic neutrophil Interleukin-1β (IL-1β) secretion in an acute mouse model of Clostridium difficile infection (C. difficile)...
Further studies revealed that SCFA activated the NLRP3 inflammasome through GPCR signaling, which conferred resistance to colitis.41 Our data demonstrated that production of RegIIIg and b-defensins in IEC was impaired in GPR43 À / À mice (Figure 1). Additionally, administration of a GPR43...
The GVHD protective effect of SCFAs requires GPR43-mediated ERK phosphorylation and activation of the NLRP3 inflammasome in non-hematopoietic target tissues of the host. These data provide insight into mechanisms of microbial metabolite- mediated protection of target tissues from the damage caused ...
The GVHD protective effect of SCFAs requires GPR43-mediated ERK phosphorylation and activation of the NLRP3 inflammasome in non-hematopoietic target tissues of the host. These data provide insight into mechanisms of microbial metabolite- mediated protection of target tissues from the damage caused ...
(P<0.05);模型组大鼠肺组织NLRP3的蛋白表达水平较空白对照组显著升高(P<0.01),各中药治疗组大鼠肺组织NLRP3的蛋白表达水平均较模型组显著降低(P值均<0.05).结论:(1)宣白承气汤可以有效治疗重症肺炎合并胃肠功能障碍,减轻全身及肺部的炎症反应,促进胃肠功能恢复,改善预后,且安全性高.(2)宣白承气汤的作用机制...
ACT001 reduces kidney inflammation and oxidative damage HFD group levels of pp65, ikkβ, NLRP3, TNFa and IL6 were considerably greater than ND mice, drastically decreased following therapy with ACT001 or PPC. These findings indicate that ACT001 can downregulate the NF-κB pathway and inhibit ...
which lead to NLRP3 inflammasome activation. Dietary fibre also shapes gut bacterial ecology, resulting in bacterial species that are more effective for inflammasome activation. SCFAs and metabolite receptors thus explain health benefits of dietary fibre, and how metabolite signals feed through to a maj...
Such interventions reduced α-syn accumulation, DA loss, and inflammatory responses, highlighting the pivotal role of the SCFA/GPR43-NLRP3 pathway in PD. The findings from this study elucidate a critical link between gut-derived metabolic changes and neuroinflammatory processes in PD via the SCFA/...
Microbiota-derived acetate enhances host antiviral response via NLRP3 ArticleOpen access06 February 2023 Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis Article25 January 2021 Fecal microbial transplantation and a high fiber diet attenuates emphysema development by...