(2008) PredGPI: a GPI-anchor predictor. BMC Bioinformatics, 9, 392.Pierlenoi, A., Martelli, P. L., and Casadio, R. (2008). PredGPI: a GPI-anchor predictor. BMC Bioinformatics 9:392. doi: 10.1186/1471-2105-9-392
GPI-anchor and GPI-anchored proteinsN-glycosylation defectsPMM2-CDGMedicine(GeneralBackground Mutations in PMM2 impair phosphomannomutase-2 activity and cause the most frequent congenital disorder of glycosylation, PMM2-CDG. Mannose-1-phosphate, that is deficient in this disorder, is also implicated...
Mannose-1-phosphate, that is deficient in this disorder, is also implicated in the biosynthesis of glycosylphosphatidyl inositol (GPI) anchors. Objective: To evaluate whether GPI-anchor and GPI-anchored proteins are defective in PMM2-CDG patients. Methods: The expression of GPI-anchor and seven ...
Since the GPI-anchor modification process occurs mostly in the ER, a disruption in the ER proteostasis, such as ER stress, may contribute to the accumulation of pro-PrP in tumor cells. Till now, AsPC-1 is the only PDAC cell line out of eight, which expresses a normal GPI-anchored PrP ...
Several eukaryotic proteins associated to the extracellular leaflet of the plasma membrane carry a Glycosylphosphatidylinositol (GPI) anchor, which is linked to the C-terminal residue after a proteolytic cleavage occurring at the so called ω-site. Computational methods were developed to discriminate prot...
"Neuronal differentiation through GPI-anchor cleavage." Cell Cycle, 16(5), pp. 388–389KEYWORDS: GDE2, glycerophosphodiesterase, glycosylphosphatidylinositol, glypican, lysophosphatidic acid, motor neuron, neuroblastoma, notch, proteoglycan, Rho GTPases...
T-cadherin is a 95 kDa glycoprotein member of the cadherin family of adhesion molecules attached to the extracellular surface of the cell membrane through a glycosyl-phosphatidylinositol (GPI)-anchor. Whether a T-cadherin ectodomain apical targeting signal or the GPI-anchor itself targets this protein...
GPI.anchor 例句 释义: 全部 更多例句筛选 1. Expression of Two Kinds of GPI-anchor Proteins and Their Clinical Implications 干细胞缺陷性疾病患者两种GPI-锚蛋白表达及临床意义 www.ilib.cn© 2024 Microsoft 隐私声明和 Cookie 法律声明 广告 帮助 反馈...
TLR4-driven signaling in BLaER1 cells. We show that this model contains glycosylphosphatidylinositol (GPI) anchor-deficient cells, which lack CD14 surface expression when differentiated to monocytes, resulting in diminished LPS/TLR4 but not TLR7/TLR8 responsiveness. This GPI anchor defect is caused ...
we show that an impairment of GPI-anchor remodeling also causes HPMRSand conclude that targeted sequencing of the genes encoding proteins in the GPI-anchor-synthesis pathway is an effective diagnosticapproach for this subclass of CDGs.In the last 2 years, individuals with characteristic pheno-typic...