长链非编码RNA GPC3-AS1卵巢癌增殖凋亡目的:探讨依托咪酯对卵巢癌细胞CAOV3增殖,凋亡的影响及其对LncRNA GPC3-AS1的调控作用.方法:体外培养人卵巢癌细胞CAOV3,使用不同剂量的依托咪酯处理细胞,另外将si-NC,si-GPC3-AS1转染至CAOV3细胞,分别将pcDNA,pcDNA-GPC3-AS1转染至CAOV3细胞后加入依托咪酯处理细胞;采用MTT...
GPC3-AS1表达明显增加(P<0.05).NSCLC组织中lncRNA GPC3-AS1表达与性别,年龄,病理类型及分化程度均无关,而与TNM分期,肿瘤大小,淋巴结转移均明显相关(P<0.05).与沉默对照组相比,沉默GPC3-AS1组A549细胞中lncRNA GPC3-AS1表达显著降低(P<0.05),细胞增殖,迁移和侵袭能力亦显著降低(P<0.05).沉默GPC3-AS1组和抑制...
GPC3‐AS1Background Long non‐coding RNA (lncRNA) is reported to be involved in multiple biological processes in numerous human tumors. Furthermore, an increasing number of studies have confirmed the involvement of lncRNA in the initiation and development of human cancers, including cervical cancer...
GPC3-AS1表达明显增加(P<0.05).NSCLC组织中lncRNA GPC3-AS1表达与性别,年龄,病理类型及分化程度均无关,而与TNM分期,肿瘤大小,淋巴结转移均明显相关(P<0.05).与沉默对照组相比,沉默GPC3-AS1组A549细胞中lncRNA GPC3-AS1表达显著降低(P<0.05),细胞增殖,迁移和侵袭能力亦显著降低(P<0.05).沉默GPC3-AS1组和抑制...
ELK1‐activated GPC3‐AS1/GPC3 axis promotes the proliferation and migration of cervical cancer cellsdoi:10.1002/jgm.3099Hu, RongZhu, ZongmingJournal of Gene Medicine