Membrane GPC3 is highly expressed in hepatocellular carcinoma (HCC) and moderately in squamous non-small cell lung cancer (SQ-NSCLC) with limited expression in normal tissues which makes it an attractive target for immune cell engagers. This study aims to develop an AI-powered algorithm to ...
GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nod...
We confirmed the absence of GPC3 expression in children using a comprehensive, non-malignant paediatric tissue array19 and, as part of eligibility before the enrolment of each patient, GPC3 expression in tumour samples was quantified by immunohistochemistry20 (Extended Data Fig. 1a–c). Patients ...
(3) Expression of GPC3 protein in HCC by immunohistochemistry Immunohistochemistry indicated normal liver tissue sections were negative for GPC3.Of all 57 cases, 68.42%(39/57) section showed the reactivity of GPC3. 82.8%(24/29) sections in ER group were positive for GPC3,while 53.6% (15/28)...
博士学位论文GPC3在肝细胞癌转移及侵袭中的作用及机制研究研究生:阮健导师:**城教授,杨洋教授摘要肝细胞癌(hepatocellularcarcinoma,HCC)是世界上最常见的恶性肿瘤之一,以亚洲和非洲高发。近些年西方发达国家的HCC发病率也呈上升趋势,尤其是美国和加拿大Ⅲ砼1。我国是世界上HCC高发地区之一,每年发病人数约为30万人,位于常...
12, 13, 14 Glypian-3 (GPC3) has been demonstrated to be highly expressed in HCC and other tumor types, and our previous study indicated that its expression in normal tissues is undetectable.15, 16 Therefore, this protein is a rational immunotherapeutic target. To investigate the potential of...
Positive rate of Hep-Par-1 expression was 81% ( 52/64 ) in HCC,100% in FNH,HA and adjacent liver tissue,9%( 1/11 ) in MAC,non-expression in other tissues. The expression of Hep-Par-1 in normal liver and HCC cells was significantly higher than in other tumors( P < 0. 05 )....
525#Background:Glypican-3 (GPC3) is a membrane-anchored oncofetal protein whose expression is largely absent in normal tissues. Significant upregulation of GPC3 protein has been observed in approximately 75% of hepatocellular carcinomas (HCC), and is associated with poor prognosis. The differential...
241839 Introduction: Glypican 3 (GPC3), an oncofetal acetyl heparan sulfate glycoprotein exhibits high expression in hepatocellular carcinoma (HCC) but low expression in normal liver tissue and chronic hepatitis. Due to its differential expression, GPC3 serves as an ideal biomarker for HCC diagnosis ...
No reactivity in seminoma, mature teratoma and normal testicular tissue was seen. Conclusion: It seems that GPC3 is a usefull marker in the histopathologic diagnosis of yolk sac tumors or yolk sac elements of mixed germ cell tumors.EBSCO_AspJournal of Mazandaran University of Medical Sciences...