Abbr. M, DNA marker; HE, heterozygous; WT, wild type. Fig.2 Detection of human GPC3 expression in brain in hGPC3 mice by WB. Abbr. M, marker; WT, wild type; HE, heterozygous; PC, positive control, Hep G2 cells. 南模生物深耕基因编辑领域,提供全方位模式生物服务,包括基因修饰成品模型供...
Abbr. M, DNA marker; HE, heterozygous; WT, wild type. Fig.2 Detection of human GPC3 expression in brain in hGPC3 mice by WB. Abbr. M, marker; WT, wild type; HE, heterozygous; PC, positive control, Hep G2 cells. 南模生物深耕基因编辑领域,提供全方位模式生物服务,包括基因修饰成品模型供...
Abbr. M, DNA marker; HE, heterozygous; WT, wild type. Fig.2 Detection of human GPC3 expression in brain in hGPC3 mice by WB. Abbr. M, marker; WT, wild type; HE, heterozygous; PC, positive control, Hep G2 cells. 南模生物深耕基因编辑领域,提供全方位模式生物服务,包括基因修饰成品模型供...
[2]Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution. [3]Long term complete response of advanced hepatocellular carcinoma to glypican-3 specific ...
Fig.2 Detection of human GPC3 expression in brain in hGPC3 mice by WB. Abbr. M, marker; WT, wild type; HE, heterozygous; PC, positive control, Hep G2 cells. 南模生物深耕基因编辑领域,提供全方位模式生物服务,包括基因修饰成品模型供应、个性化模型定制、饲养繁育、表型分析、药效评价等,满足不同实...
4. Sun B, Huang Z. Significance of Glypican-3 (GPC3) Expression in Hepatocellular Cancer Diagnosis. Med Sci Monit. 2017 Feb 16; 23:850-855. doi: 10.12659/msm.899198. PMID: 28207681; PMCID: PMC5325041 5. Guo M, Zhang H, Zheng J, Liu Y. Glypican-3: A New Target for Diagnosis and...
[3]Sun B, Huang Z, Wang B, et al. Significance of Glypican-3 (GPC3) expression in hepatocellular cancer diagnosis[J]. Medical Science Monitor, 2017, 23: 850-855. [4]Zhou F, Shang W, Yu X, et al. Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment[...
At last, in vivo model demonstrate that targeting GPC3high CAFs sensitizing the PD-1 blockage therapy in GC. In conclusion, GPC3 expression in CAFs is a critical prognostic biomarker, and targeting GPC3high cancer-associated fibroblasts sensitizing the PD-1 blockage therapy in GC.Key messages...
[6]Hsu HC, Cheng W, Lai PL. Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution. Cancer Res. 1997;57(22):5179–5184.[7]Wu Y, Liu H, Ding H. GPC-3 in hepatocellular carcinoma: current ...
其中CT011治疗GPC3阳性实体瘤的临床试验申请于2019年获得国家CDE的默示许可,2020年在Clinical Cancer Research刊登临床结果,是全球首个靶向GPC3 CAR-T细胞治疗肝细胞癌的药物。研究在经过手术治疗、局部治疗或全身系统治疗后病情发生进展的患者中开展,临床结果显示,半年、1年、3年的生存率分别为:50.3%、42.0%和10.5%;...