However, targeting STAT3 transcription factor itself is not clinically achievable, as STAT3 is required for other functions in normal cells.20,22 Thus, identification of unique upstream regulators controlling STAT3 activation in GSCs may offer new therapeutic targets for developing GSC-specific ...
Objectives. Marijuana is the most commonly used illicit drug during pregnancy. Due to high lipophilicity, cannabinoids can easily penetrate physiological barriers like the human placenta and jeopardize the developing fetus. We evaluated the impact of can
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Real-time qPCR and WB analyses suggested that the KD of Gpm6a significantly reduced the protein levels of Procr and CyclinD1, while the overexpression of Gpm6a triggered Procr and CyclinD1 activation in mammary cells (Figures S4E–S4G). We constructed a vector for shRNA expression alongside...