The fusion of viruses with cellular membranes is a critical step in the life cycle of enveloped viruses. This process is facilitated by viral fusion proteins, many of which are conformationally pH-sensitive. The specifics of how changes in pH initiate th
We hypothesized that only CCHFV-M targeting vaccines containing GP38 would be protective against CCHFV challenge. Our study confirmed the hypothesis that GP38 is required and sufficient for protection. We saw that both the GP38 + GC- and GP38 + GC+ vaccines protected 100% of mice a...
3a for dose schedule) formulated alone in PBS or with the addition of Synthetic Monophosphoryl Lipid A (MPLA), 3D(6 A)-PHAD, in a squalene-in-oil emulsion (PHAD-SE), at a dose of 5 µg PHAD and 2% SE. Each immunization was administered as a total of 100 µL, with 50...
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Series 354 Micro-Ion Vacuum Gauge Module Instruction Manual - 354008 19 3 Introduction 3.7 Emission Current There are two ranges of emission current available. Either 100 microamperes or 4 milliamperes are available as determined by the digital interface. While either range can be used continuously...
The early humoral immune response to acute HIV-1 infection is largely non-neutralizing. The principal target of these antibodies is the primary immunodominant region (PID) on the gp41 fusion protein. The PID is a highly conserved 15-residue region displa
In this study, the inhibition behavior of DMY based on pancreatic lipase (PL) assay was investigated by ultraviolet spectroscopy followed by a series of multiple-spectroscopy measurements including fluorescence spectroscopy, synchronous fluorescence spectroscopy and 3D fluorescence spectroscopy as well as the...
HIV-1 gp140 from a series of isolates were expressed in two formats, with or without a foldon trimerization tag at the C-terminus (e.g. gp140 and gp140-Foldon). The HIV-1 strains shown here include Bcon, the consensus sequence of Glade B; Ccon, the consensus sequence of Glade C; ...