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The envelope glycoprotein of the human immunodeficiency virus (HIV-1), gp120, has recently been characterized as a novel immunoglobulin superantigen (Ig-SAg) [1,2]. Analogous to the interaction of SAgs with T cells, gp120 binds to an unusually large proportion of immunoglobulins (Igs) from ...
heat-resistant method (GP) α- glucan phosphorylaseProcess for the preparation of this heat of α- glucan phosphorylase and the heat of α- glucan phosphorylase obtained by modifying the natural α- glucan phosphorylase is provided. Natural α- glucan phosphorylase, is derived from a plant, this...
Based on our finding that a common epitope exists between HIV-1 gp41 and human type I interferons (IFN-α and IFN-β), and increased levels of antibodies against human IFN-α and IFN-β were observed in HIV-1-infected individuals, we tried to explain the mechanism of...
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近日,中山大学肿瘤防治中心曾木圣教授、南方科技大学刘铮教授、中山大学孙逸仙纪念医院孔祥炜博士在学术期刊Cell Reports Medicine上在线发表题为Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus...
Residue N425 on β20 leads the conformational rearrangement of the β20/β21 strands by interacting with W112 on the inner domain and F382 on the outer domain. An accompanying shift is observed in the inner domain as helix α1 exhibits a loss in helicity and pivots away from helix α5....