Therefore, our objective was to develop a novel chronic mouse model of gout that more closely mimics the progression of gout in humans. Methods A novel chronic mouse model of gout was established by a simple method, which does not require high technical proficiency, predominantly involves daily ...
Gout clinically presents as a self-limiting disease and is a result of an inflammatory response to the MSU crystals deposited in the tissues of the host [7,8]. Aside from some rare monogenetic syndromes, gout is usually a multifaceted disorder that is precipitated by multiple risk factors that...
Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition. Gout typically presents as an acute, self-limiting inflammatory monoarthritis that affects the joints of the lower limb. Elevated serum urate level (hyperuricaemia) is the maj
Supplemental vitamin C intake may be beneficial in the prevention of gout. Gout is the most common type of inflammatory arthritis in men.1 Epidemiologic studies2 suggest that the overall disease burden of gout is substantial and growing. The identification of the risk factors for gout that are ...
Crystal-Associated Arthritis in the Elderly Since the original recognition of these conditions in 1961, a great deal has been learned about the pathogenesis, clinical manifestations, and appropriate ... CM Wise - 《Rheumatic Disease Clinics of North America》 被引量: 64发表: 2007年 Gout in the...
^ a b "Rich Man's Disease – definition of Rich Man's Disease in the Medical dictionary". Free Online Medical Dictionary, Thesaurus and Encyclopedia. Archived from the original on 14 November 2013. Retrieved 1 May 2009. ^ a b c d e f g h Eggebeen AT (2007). "Gout: an update". ...
Gout is the most prevalent inflammatory arthritis disease in men which results from monosodium urate (MSU) crystals deposition in joints and periarticular tissues. MicroRNAs (miRNAs) are small noncoding RNAs which functions in post-transcriptional regulation of gene expression. Recent studies suggest ...
7 In people who have had prior gout flares and have persistent hyperuricemia, MSU crystals are typically detectable by microscopy and advanced imaging of the joint, even after the gout flare has resolved,8, 9, 10 supporting the concept that gout is a chronic disease of MSU crystal deposition....
Pseudogout mimicking systemic disease. Pseudogout is a great mimicker of other forms of arthritis, often leading to diagnostic confusion. The association of pseudogout and fever is less widely recognized. We describe eight patients in whom fever was a prominent manifestation ... D Bong,R Bennett...
There was no clear correlation between gout and hypertension, hyperlipidemia, cardiovascular disease, and diabetes (Supplementary Table S2). Fig. 1: Genetic alteration of NUMB gene in patients with inherent hyperuricemia and gout. a The pedigree of family with inherent hyperuricemia and gout. The ...