Miller, 3rd, et al., Gout, urate-lowering therapy, and uric acid levels among adults in the United States. Arthritis Care Res (Hoboken), 2015, 67: 588-592.Stephen P., JuraschekLara C., KovellEdgar R., MillerAllan C., Gelber. (2014) Gout, Urate Lowering Therapy and Uric Acid ...
1.A disturbance of uric-acid metabolism occurring chiefly in males, characterized by painful inflammation of the joints, especially of the feet and hands, and arthritic attacks resulting from elevated levels of uric acid in the blood and the deposition of urate crystals around the joints. The con...
Sustained reduction in serum urate levels using urate-lowering therapy is vital in the long-term management of gout, which aims to dissolve MSU crystals, suppress gout flares and resolve tophi. Allopurinol is the first-line urate-lowering therapy and should be started at a low dose, with ...
49,50 Elevated serum urate levels possibly underlie the association with many of the comorbidities that are seen in this crystalline arthritis (Table 1). In the following sections, we summarize the evidence on the association of gout and selected common comorbidities. Table 1. Comorbidities in ...
Gout. Needles of urate crystals seen on polarizing microscopy. View Media Gallery Many conditions and drugs have been associated with an increase in plasma (and subsequent synovial) urate levels, particularly metabolic syndrome.[8]A genetic predisposition for hyperuricemia exists; except in rare genetic...
Specifically, we found a negative association between vitamin B12levels and urate levels, with a β coefficient of0.324 (95% CI 0.0581 to0.0066,P=0.0137) per one standard deviation (SD) increase. Similarly, a negative association was observed between folate levels and gout risk, with an odds ...
1.A disturbance of uric-acid metabolism occurring chiefly in males, characterized by painful inflammation of the joints, especially of the feet and hands, and arthritic attacks resulting from elevated levels of uric acid in the blood and the deposition of urate crystals around the joints. The con...
摘要: Background Ferritin positively associates with serum urate and an interventional study suggests that iron has a role in triggering gout flares. The objective of this study was to further explore the...关键词: Urate, Gout, Ferritin, Iron, Association, Causal, Mendelian randomization ...
I was content to take my daily urate-lowering drugs, anti-inflammatories during an attack, and try to stick to my “avoidance” diet as best I could. But I still suffered those agonizing recurring gout flares! I suppose I had just accepted my fate… that I had gout… that there was ...
Many patients who suffer from Renal disease may be put on urate clearing diuretics such as low dose aspirin, furosemide, etambutol , phenylbutazone, ethacynic acid, pyrazinamide or nicotinic acid. The above drugs have all been implicated in Gout diseases and attacks. ...