In addition to R620W, other PTPN22 variants have been reported to associate with or confer resistance to the development of autoimmune disease. For example, an R263Q mutant has been shown to be protective against SLE and RA and is reportedly a loss-of-function variant as demonstrated by in ...
Once released, sCD163 also recognizes and binds to fibronectin, which then acts as a bridge between sCD163 and the staphylococci. This binding promotes the effective clearance (enhanced phagocytosis and killing) of S. aureus by professional phagocytes, while dampening the induction of proinflammatory...