We found a novel APP mutation (A673V) in the homozygous state in a patient with early-onset AD-type dementia and in his younger sister showing initial signs of cognitive decline. It is noteworthy that the heterozygous relatives were not affected, suggesting that this mutation is inherited as ...
Think about people who have donated a kidney. That one kidney left over suddenly has to handle more protein. If higher levels of protein damaged healthy kidneys, we would see it in donors. But we don’t. That one kidney just adapts and donors have no increased risk for kidney disease. M...
AMYLOID PROTEIN PRECURSORS, GENETIC PROBES, ANTIBODIES, AND METHODS OF USE Two different forms of Amyloid Protein Precursor (APP) can be detected and differentiated using nucleic acid probes, and hybridization assay techniques. The two forms of APP differ by the existence of an exon in one form ...
Recent molecular models and crystallographic analysis of the major protein of peripheral myelin have provided new insights into the molecular basis of membrane adhesion in myelin. These studies have proved useful in understanding the molecular basis of clinical phenotypes in certain demyelinating neuropathies...
摘要: Monoubiquitination is a reversible protein modification that, much like phosphorylation, helps regulate a wide range of processes including endocytosis, transcription, and DNA repair. But can monoubiquitination affect the activity of a common metabolic enzyme? As...
Mammalian target of rapamycin (mTOR) is one such protein... JP Dutcher - 《Current Oncology Reports》 被引量: 281发表: 2004年 Oligosaccharides: application in infant food M. Rivero-Urgell and A. Santamaria-Orleans, "Oligosaccha- rides: application in infant food," Early Human Development, ...
Complement is activated by three different recognition pathways (classical, alternative, and lectin), all of which lead to sequential enzyme activation, protein cleavage, and induced function-enabling protein conformational changes (Fig.1). The classical complement pathway is activated when the C1 comple...
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem. 2007;282:37298–302. CAS PubMed Google Scholar Loos B, Engelbrecht A-M, Lockshin RA, Klionsky DJ, Zakeri Z. The variability of autophagy and cell death susceptibility: Unanswered ...
“Good” receptors internalize Aβ or promote its transcytosis out of the brain, whereas “bad” receptors bind oligomeric forms of Aβ that are largely responsible for the synapticloss, memory impairments, and neurotoxicity that underlie Alzheimer disease. The prion protein both removes Aβ from ...
To investigate the effects of inhibiting HDAC3, Hiebert and colleagues genetically engineered mice lacking the protein. However, the mice died before birth. Even when grown in cell culture, mouse cells lacking HDAC3 died. “The question is: why are they dying? And what we found was kind of...