The Golgi apparatus plays a central role in the numerous traffic tasks in cells. Whereas the well-investigated chemical signaling is sufficient to explain the information processes in the secretory output of cells, it is insufficient to do that for the substitution of structural elements in the ...
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The user's task is not just to interact with the computer, but to get a job done. Thus understanding the user's task involves understanding the user's task domain and the user's larger job goals. Many systems are designed for ordinary people, who presumably lack specialized knowledge, and...
Using APP-paGFP, we show that APP is rapidly trafficked from the Golgi apparatus to the lysosome; where it is rapidly cleared. Chloroquine and the highly selective γ-secretase inhibitor, L685, 458, cause the accumulation of APP in lysosomes implying that APP is being cleaved by secretases ...
Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid Joshua HK Tam1,3, Claudia Seah1 and Stephen H Pasternak1,2,3* Abstract Background: Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid peptide (Aβ...
Golgi apparatus, organelle of eukaryotic cells that is responsible for transporting, modifying, and packaging proteins and lipids. The Golgi apparatus is made up of a series of flattened, stacked pouches called cisternae and is located in the cytoplasm n
is increased. Notably, WT cells cultured at a high mannose concentration display similar changes with increased retention of α-DG, altered structure of the Golgi apparatus, and a decrease in furin activity. In summary, our data underline the importance of a balanced mannose homeostasis for the ...
Rab6 is a key regulator of the Golgi apparatus, the central sorting organelle of eukaryotic cells. Here the authors use cryo-electron microscopy and functional experiments to reveal how Rab6 is activated by the Ric1-Rgp1 complex. J. Ryan Feathers ...
The job of the Golgi apparatus is to process and bundle macromolecules like proteins and lipids as they are synthesized within the cell. Ruzl Jade Ladion Matlani High tolbutamide alone, in contrast increases the Golgi complex, coated vesicles, multivesicular bodies and cytosegresomes. springer ...
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