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1d). Similarly, the triple knockdown of ZnT5/6/7 decreased the [Zn2+] in all Golgi cisternae (Supplementary Fig. 5), suggesting that ZnT5/6/7 predominantly govern zinc homeostasis in the Golgi apparatus. Of note, the single knockdown of ZnT4, ZnT5/6 and ZnT7 significantly reduced the...
Importantly, we found that 26S proteasomes are localized to the cytosolic surface of the Golgi apparatus, enabling localized degradation and regulation of Golgi organization. Aberrations in Golgi-localized degradation disrupt the Golgi architecture and consequently lead to cell death in multiple myeloma ...
The Golgi apparatus is a central meeting point for the endocytic and exocytic systems in eukaryotic cells, and the organelle’s dysfunction results in human disease. Its characteristic morphology of multiple differentiated compartments organized into stacked flattened cisternae is one of the most recogniza...
The mechanisms by which the Golgi apparatus (GA) impacts on cell invasion are poorly understood. The human Golgi Anti-Apoptotic Protein (hGAAP, also known as TMBIM4) is a highly conserved Golgi cation channel that modulates intracellular Ca2+ fluxes. Human GAAP is expressed in all human tissue...
A Predicted WPB size distribution (stars) compared to real data (blue bars), where 1Q-WPBs display instability, α, greater than longer organelles. B HUVECs were fixed and processed to label the Golgi apparatus with an anti-TGN46 antibody and WPBs and cell boundaries as described in Fig....
Severe hypoxia or HIFs also modulate homeostasis of the endoplasmic reticulum (ER) and the Golgi apparatus (GA). In the former, it typically evokes the unfolded protein response (UPR) [16,17], while in the latter it interferes mainly with Golgi-associated trafficking and glycosylation events [...
Nilsson T, Rabouille C, Hui N, Watson R, Warren G (1996) The role of the membrane-spanning domain and stalk region ofN-acetylglucosaminyltransferase I in retention, kin recognition and structural maintenance of the Golgi apparatus in HeLa cells. J Cell Sci 109:1975–1989 ...
innocuous control protein (Supplementary Fig.2a). This suggests that ARF1 is critically involved at the Golgi apparatus in regulating lipid oxidation products as a result of BFA treatment. Interestingly, loss of Arf1 inCandida albicanswas shown to result in increased intracellular ROS accumulation30....
(LTA1) that shares sequence similarities with cholera toxin, also disrupts Golgi apparatus in a pattern that is reminiscent of the actions of BFA47. This suggests that the mechanism of SIRT2's anti-bacterial role is potentially broader. One limitation of our study is that we used a mouse ...