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We tested whether the transmembrane proteins are involved in the uptake of L-or D-NP-aNLRP3 by astrocytes (MA-C), brain microvascular endothelial cells (BMEC) and microglia (BV2), among which MA-C and BMEC cells mainly served to restrict movement of substances from the circulating blood to...
We tested whether the transmembrane proteins are involved in the uptake of L-or D-NP-aNLRP3 by astrocytes (MA-C), brain microvascular endothelial cells (BMEC) and microglia (BV2), among which MA-C and BMEC cells mainly served to restrict movement of substances from the circulating blood to...
a disease15,16. Important prerequisites for a working all-in-one platform using hybrid NPs as drug carriers are the circulation time in blood and the effectiveness of accumulation in tumor tissue17,18. Consequently, it is of utmost importance to understand how multifunctional NPs interact with bio...
U. et al. Identification of prostate cancer mRNA markers by averaged differential expression and their detection in biopsies, blood, and urine. Proc. Natl. Acad. Sci. (USA) 104, 2343–2348 (2007). 27. You, C. et al. Detection and identification of proteins using nanoparticle–fluorescent ...
Multimodal nanoparticles, utilizing quantum dots (QDs), mesoporous silica nanoparticles (MSNs), and gold nanoparticles (Au NPs), offer substantial potential as a smart and targeted drug delivery system for simultaneous cancer therapy and imaging. This me
Due to their simplicity and unnecessity of laboratory-based requirements, all these systems have a clear potential to become portable sensors and to be applied for point-of-care (POC) diagnostics. A good example has been developed by Wu et al. (Fig.7e) to detect occult blood in urine, com...
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The protein corona is known to trigger immune response, eventually leading to clear- ance of the nanoparticles from blood circulation1. Among other factors, the nature of protein corona on nanoparticles is governed by the size, shape, surface charge and surface chemistry of the nanoparticles26. ...
Moreover, the acute and chronic toxicity of the GNMs depends on the route of administration, test organism, sex, surface-coating agents, dosage, and size [33,199,200]. Zhang et al. (2010) reported that AuNPs (13.5 nm) reduced splenic index, red blood-cell counts, and body weight of ...