Gonadotropin-releasing hormone (GnRH) is released from hypothalamic neurons into the hypophyseal-portal blood system following enzymatic cleavage of the decapeptide from a large precursor (proGnRH) molecule. The purpose of this study was to determine whether the ability of GnRH-producing neurons to ...
Once GnRH is released from the hypothalamus, it travels to the pituitary gland. There, it binds toGnRH receptors on the surface of gonadotrope cells, which make and release the gonadotropins: LH and FSH [4]. GnRH and its receptors can also be found outside the hypothalamus and pituitary....
In mammals, GnRH is released from nerve endings into the hypophyseal portal system in a pulsatile manner to stimulate the synthesis of the gonadotropes, FSH and LH, from the anterior pituitary. Thus, the communication between the hypothalamic GnRH cells and the pituitary occurs via a localized ...
GnRH / biochem / abbreviation for gonadotrophin-releasing hormone: a peptide that is released from the brain and stimulates the pituitary gland to secrete gonadotrophic hormones that act in turn on the sex glands Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William ...
GnRHR promoter activity is also stimulated by the neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP). Hypothalamic PACAP is released into the portal vasculature, binding to specific PACAP receptors on gonadotrope cell membranes and acting to augment gonadotropin secreti...
When perifused in Ca(2+)-free medium, pituitary glands from juveniles of both sexes and from adult cockerels but not those from laying hens, released LH in response to cGnRH-I. This release occurred at the same time as the spike phase of the response seen in the presence of extracellular...
POA. cGnRH-I is released from the median eminence and transported through the hypophysial tract to the anterior pituitary. cGnRH-I plays an important physio- logical role in stimulating the release of gonadotropins, luteinizing hormone (LH), and follicle-stimulating hor- mone (FSH) from the ...
Here GnRH is released into the pituitary portal blood vessels for delivery to the anterior pituitary to elicit the secretion of luteinizing hormone (LH) and follicle- stimulating hormone (FSH)1. Alterations in the development of this system or in the secretion of GnRH are associated with a ...
GnRH is a key neurohormone responsible for the central regulation of gonadotropin (LH, FSH) secretory function. It is released from the nerve terminals into the hypophysial-portal circulation in a pulsatile manner and, at pituitary level, it interacts with high-affinity, G protein-coupled recepto...
During the perifusions, hCG (determined by enzymeimmunoassay) was found to be released spontaneously in a pulsatile fashion. Pulse amplitudes and frequencies of this episodic hCG secretion were increased in response to GnRH, but not affected by GnRH antagonist. Also, GnRH stimulated the hCG ...