E. Optogenetic activation of GnRH neurons reveals minimal requirements for pulsatile luteinizing hormone secretion. Proc. Natl Acad. Sci. USA 111, 18387–18392 (2014). Article CAS PubMed PubMed Central Google Scholar Yu, B., Tang, Y. & Cai, D. Brain is an endocrine organ through ...
Gonadotropin-releasing hormone (GnRH)Leutinizing hormone (LH)Follicle-stimulating hormone (FSH)Although hormonal response abnormalities in depression have been demonstrated in several hypothalamic-pituitary-target organ axes after a variety of neuroendocrine challenge tests, studies of hypothalamic-pituitary-...
The use of maximal or supramaximal doses of gonadotropin-releasing hormone (GnRH) in early studies (150–600 μg) may have masked the presence of more subtle disturbances in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) responsiveness in depression. We hypothesized that ...
Immune stress induced by lipopolysaccharide (LPS) influences the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) secretion. Presence of LPS interacting Toll-like receptor (TLR) 4 in the hypothalamus may enable the direct action of LPS on the GnRH/LH secretion. So, the aim of the...
ARTICLE Received 26 Jun 2015 | Accepted 29 Oct 2015 | Published 12 Jan 2016 DOI: 10.1038/ncomms10055 OPEN Novel role for anti-Mu¨llerian hormone in the regulation of GnRH neuron excitability and hormone secretion Irene Cimino1,2, Filippo Casoni1,2,w, Xinhuai Liu3, Andrea Messina1,2, ...
1.4 GnRH 的研究背景促性腺激素释放激素(gonadotropin-releasing hormone, GnRH))是第 2 个被分离鉴定 的下丘脑促垂体激素,1971 年 Schally 从猪下丘脑中获得 GnRH 鉴定其结构为 10 肽[ 78],含有 9 种不同类型的氨基酸,分子长度以及部分氨基酸的序列相对较为保守[79]。 在下丘脑,约 85%的 GnRH 分布在正中...
The drug innovations in the field of prostate cancer have been gonadotropin-releasing hormone (GnRH) agonists (Labrie et al. 1980, 1996, 2005a) used to achieve medical castration and the pure antiandrogens or compounds having exclusive antagonistic activity at the androgen receptor (AR) (Neri et...
14 Sox9a (SRY (sex determining region Y)-box 9a) Produces anti-Müllerian hormone (AMH) in Sertoli cells to inhibit the formation of female reproductive system. It also regulates expression of other genes like Testis determining factor (TDF), DAX1 (dosage-sensitive sex reversal, adrenal hypopla...
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons control pituitary gonadotropin secretion and gametogenesis. In the course of development, these neurons migrate from the olfactory placode to the hypothalamus. The precise molecular mechanism of this neuronal migration is unclear. Here, we investigat...
Treatment with the GnRH agonist, leuprolide, is commonly used in gender dysphoric youth after the initial onset of puberty to delay endogenous puberty progression and to provide more time for individuals to decide whether to initiate feminizing or masculinizing hormone therapy to affirm their gender ...