GNAS反义RNA 1侵袭迁移MAPK信号通路目的 阐明长链非编码RNA GNAS反义RNA 1(GNAS-AS1)在肺鳞癌(LUSC)进展中的生物学作用和机制.方法 UALCAN在线分析LUSC组织的GNAS-AS1水平,荧光定量PCR检测LUSC细胞的GNAS-AS1水平.向SK-MES-1细胞分别转染靶向GNAS-AS1的小干扰RNA(GNAS-AS1-siRNA),无关序列siRNA-NC或表皮细胞生长...
基因筛查在GNAS-AS1基因编码区检测出Exon 5E杂合缺失突变。予补充元素钙720 mg/d、普通维生素D 375 U/d、活性维生素D 0.5 μg/d、氯化钾3 g/d后,血钾、磷恢复正常,血钙、镁接近正常低限。假性甲状旁腺功能减退症Ⅰb型可伴有低钾低镁血症。 展开 ...
GNAS-AS1/miR-4319/NECAB3 axis promotes tumor progression of NSCLC by altering macrophage polarization. This novel mechanism may provide potential strategy for NSCLC treatment.doi:10.1007/s10142-019-00696-xZhixin LiDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai,...
体格检查显示,患者身材矮小,似有圆脸,短颈,束臂加压试验阳性;高甲状旁腺素,低血钙,高血磷,低血钾,低血镁,低尿钙,低尿磷.颅脑核磁共振成像( MRI)显示双侧基底节区少量钙化.基因筛查在GNAS-AS1基因编码区检测出Exon 5E杂合缺失突变.予补充元素钙720 mg/d,普通维生素D 375 U/d,活性维生素D 0.5 ...
LncRNA GNAS-AS1 knockdown inhibited cell proliferation, migration, and invasion by regulated miR-490-3p partly at least. Conclusions LncRNA GNAS-AS1 can be used as a prognostic indicator and its inhibition suppress the development of OS, suggesting its value as novel therapeutic strategies in OS....
LncRNA GNAS-AS1 participates in the proliferation and migration of gastric cancer cells by regulating the miR 449a/Notch1 axisXU LiHU ShanshanZHAO HaimingJournal of Practical Medicine / Shiyong Yixue Zazhi
GNAS-AS1/miR-4319/NECAB3 axis promotes migration and invasion of non-small cell lung cancer cells by altering macrophage polarizationdoi:10.1007/S10142-019-00696-XZhixin LiChangjiang FengJunhong GuoXuefei HuDong XieFunct Integr Genomics
GNAS-AS1miR-2116-3p细胞增殖迁移侵袭目的:探讨GNAS-AS1对卵巢癌细胞增殖,迁移和侵袭的影响及可能机制.方法:RT-qPCR法检测正常人卵巢上皮细胞HUM-CELL-0088及卵巢癌细胞系SKOV3,OVCAR3和A2780细胞中GNAS-AS1和miR-2116-3 p表达水平.以SKOV3细胞为研究对象,分别转染GNAS-AS1小干扰RNA,miR-2116-3 p模拟物或抑制...
GNAS-AS1KeloidRUNX2miR-188-5pMolecular and Cellular Biochemistry - Keloid is a common dermis tumor, occurring repeatedly, affecting the quality of patients' life. Long non-coding RNAs (lncRNAs) have crucial regulatory...doi:10.1007/s11010-022-04538-6Liu, Yun...
GNAS-AS1 N6-methyladenosine (m6A) modification level was detected by methylated RNA immunoprecipitation sequencing. The combined targets of miR-34a-5p were validated using a dual-luciferase reporter assay. BALB/C nude mice were selected for subcutaneous tumor validation. Chidamide at a dosage of 25...