Cyclic di-GMP in Tumour Growth Control Among small molecule drugs that appear to be capable of controlling tumour growth, cyclic diguanosine monophosphate or cyclic di-GMP (c-di-GMP) has attracted much attention. The immune-stimulatory properties of c-di-GMP were recognised some time ago (Kara...
Date Feb. 6, 1997A compound having the formula (I) and solvates thereof, wherein: R0 represents hydrogen, halogen or C1-6 alkyl; R1 represents hydrogen or C1-6alkyl; R2 represents the bicyclic ring which may be optionally substituted by one or more groups selected from halogen and C1-3...
Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified nov... Kots, A.Y.,K Bian,F Murad - 《Current Medicinal Chemistry...
Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions Two-component systems (TCS) are universal among bacteria and play critical roles in gene regulation. Our understanding of the contributions of TCS in the b... EA Rogers,...
Biofilms serve as crucial cues for settlement and metamorphosis in marine invertebrates. Within bacterial systems, c-di-GMP functions as a pivotal signaling molecule regulating both biofilm formation and dispersion. However, the molecular mechanism of ho
et al. Nitric Oxide (NO)-Cyclic GMP (cGMP) Responses of Premature and Adult Rat Brain Synaptosomes to Morphine Sulfate (MS) and Morphine-3-Glucuronide (M-3-G). Pediatr Res 45, 72 (1999). https://doi.org/10.1203/00006450-199904020-00430 Download citation Issue Date01 April 1999 DOIhttps...
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis. Numerous studies have conducted comprehensive analysis of c-di-GMP. However, the mechanisms by which certain environm...
We tested the hypothesis that increased O2 consumption and inotropy after reduction of myocardial cyclic (cGMP) are mediated through L-type channels. Anesthetized, open-chest New Zealand white were divided into four groups. Hearts were exposed to control vehicle (n = 8); LY83583 (LY, 10(-3)...
C-di-GMP: the dawning of a novel bacterial signalling system. Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) has come to the limelight as a result of the recent advances in microbial genomics and increa... U R?Mling,M Gomelsky,MY Galperin - 《Molecular Microbiology》 ...
In bacteria, motility and its regulation contribute to the colonization of hosts and other habitats, biofilm formation, virulence, and predation1. The ubiquitous second messenger cyclic di-GMP (c-di-GMP) is a key regulator of bacterial motility2,3,4. Generally, high c-di-GMP levels inhibit ...