Voltage-gated proton channels are abundantly expressed in immune cells, including microglia, and play crucial roles in sustaining phagocytosis. We show that both lidocaine and bupivacaine increase the intracellular pH of microglia by their weak base properties and, consequently, inhibit proton channels. ...
The specific mechanisms that promotes metastasis to bone are not completely understood, however, it has been shown that alterations in tumour cell adhesion to the bone marrow affect the metastatic potential of PCa cells. This suggests that the bone microenvironment is an important player in the ...