Here, we detail a unique case of a child exhibiting diffuse spinal nerve root hypertrophy in the context of epidermal nevus syndrome driven by molecularly confirmed KRAS G12D mosaicism, treated with the MEK 1/2 inhibitor selumetinib. Herein, we report the response of thi...
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Total protein, measured for each well, was used to normalize data between replicate wells. The data are presented as the averages ± S.D. of at least four determinations. To investigate the role of MEK activity on ATF4 translation per se, HepG2 cells were transiently transfected, using the...
reported in patients treated with MEK162. Please contact your doctor to seek immediate medical attention for any unusual signs or symptoms that may indicate bleeding, e.g. bruising, blood in vomit, black tarry stools, difficulty speakin 灵菌事件,包括流血在胃,肚腑和脑子在患者报告了治疗与MEK162...
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MEK signaling is required for phosphorylation of eIF2alpha follow- ing amino acid limitation of HepG2 human hepatoma cells. J Biol Chem 283: 10848 -10857, 2008.Thiaville MM, Pan YX, Gjymishka A, Zhong C, Kaufman RJ, Kilberg MS (2008) MEK signaling is required for phosphorylation of eIF...
Reshaping the Tumor Microenvironment of KRASG12D Pancreatic Ductal Adenocarcinoma with Combined SOS1 and MEK Inhibition for Improved Immunotherapy Responsedoi:10.1158/2767-9764.CRC-24-0172KRAS inhibitors have demonstrated exciting preclinical and clinical responses, although resistance occurs rapidly. Here, ...
Herein, mesoporous nanocrystalline NiO catalyst has been prepared as pure and modified with different wt% F﹊ons or K 2 O and used to produce Methyl ethyl ketone (MEK) as a potential fuel/solvent. XRD analysis of the promoted catalysts confirmed the formation of Ni﹎etal covered by the host...
The catalyst was modified with different wt % F-ions or K2O and used to produce Methyl ethyl ketone (MEK) as a potential fuel/solvent. XRD analysis of the promoted catalysts confirmed the formation of Ni-metal covered by the host oxide, compared with pure NiO, especially for the promoted ...