NEO-201 also binds to gMDSCs, defined as HLA-DRneg/CD33+/CD15+/ CD14neg/CD66b+cells. In patients with durable SD, a patient with HNSCC (SD >11 months) showed >50% reduction of nTregs and >90% of gMDSCs at C3D1 (beginning of cycle 3) compared to baseline. One patient with ...
Here, we dissected the composition of immune cells that constitute the lung PMN of osteosarcoma and further explored the role of tumor-derived EVs during this process. We showed that granulocytic myeloid-derived suppressor cells (gMDSCs) significantly accumulated in the lung PMN of an osteosarcoma ...
Myeloid-derived suppressor cells (MDSCs), which include monocytic (mMDSCs) and granulocytic (gMDSCs) cells, are an immunosuppressive, heterogeneous population of cells upregulated in cancer and other pathologic conditions, in addition to normal conditions of stress. The origin of MDSCs is debated,...
(Tregs) and granulocytic myeloid-derived suppressor cells (gMDSCs) via ADCC and complement-dependent cytotoxicity.2 Resistance to PD-1/PDL1 blockade may be due to accumulation of iSCs in the tumor microenvironment.3 Elevated neutrophil-to-lymphocyte ratio (NLR) correlates with poor prognosis.4 We...