membrane transmigration in vitro. J Immunol. 1995 May 1;154(9):4379–89.Product Name:GM6001Cat. No.:HY-15768CAS No.:142880-36-2Molecular Formula:C 20H 28N 4O 4Molecular Weight:388.46Target:MMP Pathway:Metabolic Enzyme/Protease Solubility:DMSO: ≥ 47 mg/mL www.MedChemExpress.com ...
GM 6001 (GM6001) 是一种有效的广谱基质金属蛋白酶 (MMP) 抑制剂,抑制 MMPs (IC50s, MMP-1 为 1.5 nM;MMP-2 为 1.1 nM;MMP-3 为 1.9 nM;MMP-9 为 0.5 nM ),对人皮肤成纤维细胞胶原酶 (MMP-1) 的 Ki 为 0.4 nM。 Cas No.142880-36-2SDF ...
solubility DMSO: 5mg/mL form Off-white solid pka 11.33±0.46(Predicted) color off-white Safety Information MSDS Information GM 6001, NEGATIVE CONTROL Usage And Synthesis General Description A useful negative control for the MMP inhibitor GM 6001 (Cat. No. 364205). Biochem/physiol Actions Primar...
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with aKiof 0.4 nM for human skin fibroblast collagenase (MMP-1). IC50& Target Fibroblast col...
Potent broad-spectrum hydroxamate inhibitor of matrix metalloproteinases (MMPs). Ki values have been reported for the following human MMPs: MMP-1 (fibroblast collagenase): 0.4nM; MMP-2 (gelatinase A): 0.5nM; MMP-3 (stromelysin-1): 27nM; MMP-7 (matrilysin): 3.7nM; MMP-8 (neutrophil collag...
GM6001, GM-6001 is a potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8; and Ki = 200 pM for MMP-9). GM-6001 prevents the rel...