大剂量GM1治疗可显著改善SCA3患者的共济失调症状。 Chen YK, Tian HY, Zhu QY, Zhang R, Liang DX, Wang JQ, Feng RY, Qin C, Ma MM, Jiang H, Tang BS, Ding XB, Wang XJ. Potential Disease-Modifying Effects of Ganglio...
神经节甘脂(Gangliosides)是存在于神经细胞膜上的一种重要的醣脂,正常情况下会被溶小体中的β -galactosidase酵素所分解。如果β-galactosidase缺乏或酵素功能不良,导致GM1神经节糖堆积在神经细胞或其他内脏组织中,便会产生临床症状。 发生率: 曾有报告指出马尔他的人口统计,...
We dedicated significant research resources over many years to better understand the mechanism of action of GM1 Ganglioside for neurological disorders, alzheimer’s disease, parkinson’s disease
ConclusionsThe diagnosis and classification of GM1 ganglioside storage disease need to integrate the clinical features, exome sequencing and β-galactosidase activity assay. Bioinformatics analysis is helpful to predict the effect of mutations on protein structure and function. KEYWORDS: Gangliosidosis, GM1...
GM1-ganglioside-bound Aß (GAß)SeedConformational transitionAssembly and deposition of amyloid -protein (A) is an invariable and fundamental event in the pathological process of Alzheimer's disease (AD). To decipher the AD pathogenesis and also to develop disease-modifying drugs for AD, ...
and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF) by di...
北京大学第六医院张岱教授团队,西湖大学/清华大学施一公教授和周瑞博士团队在 Advanced Science 期刊发表了题为:Preferential Regulation of γ-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer’s Disease 的研究论文,对GM1促进Aβ生成以及在AD发生发展中的作用...
Presentations.. References Scrapie Sheep Summary HOME WELCOME Based on the scientific literature, GM1 ganglioside may help those living with Huntington’s, Parkinson’s, and Alzheimer’s Disease in addition to other neurological diseases.We are passionate about what GM1 may be able to offer people ...
Previous work demonstrated that short-term (i.e., 16 weeks) use of GM1 ganglioside resulted in significant symptom reduction in Parkinson's disease (PD) patients. As GM1 use may have long-term benefit for PD patients, the present study was conducted to evaluate the long-term safety and ...
and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF) by di...