总之,我们的研究结果揭示了一种CIS调节机制,该机制阐明了GM-CSF在MØ分化中的相反作用,并揭示了GM-CSF在控制过敏性炎症中的作用。 英文摘要 The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to dif...
Cell source and quantitative expression of GM-CSF and proteins associated with pro-inflammatory (GM-CSF-driven) and anti-inflammatory (M-CSF-driven) macrophage polarization (activin A, TNF伪, MMP12, and CD209, respectively) were assessed in ST CD163 macrophages by multicolor...
First, a neutralizing anti-GM-CSF antibody was added to conditioned media from shSnail14T1 cells and macrophage polarization capacity of this GM-CSF-neutralized conditioned media assessed with WT BMDM. Neutralization of GM-CSF resulted in a macrophage polarization profile seen when culture supernatant ...
et al. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity 15, 557–567 (2001). Article CAS PubMed Google Scholar Krausgruber, T. et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat. Immunol. 12, 231...
在一个实施方案中,所述gm-csf负调节剂可以用于维持治疗以在已经接受急性主动脉夹层的初次手术修正的受试者中预防复发性主动脉夹层。在另一个实施方案中,所述gm-csf负调节剂可以用于维持治疗以在患有慢性主动脉夹层,即腹部夹层的受试者中预防主动脉夹层进展,其中手术是不太有利的,这是因为截瘫风险较高。粒细胞巨...
This identified GM-CSF as a critical regulator of macrophage activation in intestinal inflammation, which was primarily produced by innate lymphocytes, particularly ILC3s. In mouse models of intestinal infection and inflammation, we found that GM-CSF regulated the maturation and polarization of ...
A role for G-CSF and GM-CSF in nonmyeloid cancers. Cancer Med. 2014;3(4):737–46. Article PubMed PubMed Central CAS Google Scholar Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma ...
A novel pathway involving β-catenin and transcription factor 4 has been proposed to influence lineage choice during myeloid differentiation governed by GM-CSF [39]. Macrophage populations have been broadly classified into M1 and M2 polarization states, in an attempt to define their diverse function ...
A role for G-CSF and GM-CSF in nonmyeloid cancers. Cancer Med. 2014;3(4):737–46. Article PubMed PubMed Central CAS Google Scholar Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma ...
Here we describe a major fault in the widely used DC–inflammasome model of bone marrow–derived dendritic cells (BMDCs) generated with the cytokine granulocyte–macrophage colony-stimulating factor (GM-CSF). We found that among GM-CSF bone marrow–derived cell populations, monocyte-derived ...