目的:通过观察Transwell小室筛选的高侵袭性C6细胞中组织金属蛋白酶抑制剂-2(tissue inhibitor of metalloproteinase-2, TIMP-2)的表达,探讨基质金属蛋白酶-2(matrix metalloproteinase-2, MMP-2)及TIMP-2在胶质瘤侵袭中的作用机制.方法:通过Transwell小室筛选出一种更具有侵袭能力的C6-C1细胞,用细胞损伤愈合实验及Trans...
Novel therapies that combine immune checkpoint inhibitors with anti-angiogenic agents (e.g. atezolizumab and bevacizumab) or tyrosine kinase inhibitor (e.g. pembrolizumab and lenvatitinib) have recently demonstrated promise in advanced HCC, although there are limiting side effects11,12,13,14. ...
The inorganic inhibitor diprotin A, a known inhibitor of CD26 activity,31 was used as positive control in most experiments. The effect of TFPI on CD26 activity was less pronounced than the effect of diprotin A. The effect of TFPI on CD26 activity of KLS cells could be seen as early as...
The phenotype of the Simpson-Golabi-Behmel syndrome patients and GPC3-deficient mice, as well as gene transfection experiments indicate that GPC3 can act as an inhibitor of cell proliferation and survival. It has been previously shown that GPC3 expression is downregulated in mesotheliomas and ovarian...
A: JM2 rat hepatocellular carcinoma cells were treated with Syk inhibitor at 0.1 and 0.4 μg/mL for 5 hours, and total proteins were analyzed by Western blot for Yap, ezrin, and phosphorylated (p)-ezrin (Thr567). B: JM2 cells were transiently transfected with pCMV6-Syk plasmid, and ...
protein binding heparan sulfate proteoglycan binding peptidyl-dipeptidase inhibitor activity molecular_function peptidase inhibitor activity 参与通路 branching involved in ureteric bud morphogenesis kidney development biological_process negative regulation of cell proliferation organ morphogenesis anterior/posterior ax...
Cat nr AE00138 Product Datasheet Recombinant Mouse Antibody, clone rGPC3/863 to: Glypican-3, Gpc3 Glypican 3; Glypican-3; Intestinal protein OCI-5; SGBS1 inhibitor; DGSX; GPC3; GTR2-2; MXR7; OCI-5; OCI5; SDYS; SGB; SGBS Cellular localization Plasma membrane, cell surface and ...
Treatment with 20 umol of Ezrin inhibitor led to significant cell death selectively in JM2 cells in vitro. Conclusions Both HGF/Met and CD81 mediate p-Ezrin activity and enhance nuclear Yap levels. These pathways in normal hepatocytes are inhibited by GPC3 and low HGF/Met activity. In human ...
Antibody to GPC3 according to this invention has higher ADCC activity and CDC activity compared to traditional antibody.;EFFECT: antibody by present invention can be used as cell growth inhibitor, anticancer agent and means for diagnostics of cancer.;3 cl, 20 dwg, 1 tbl, 27 exNAKANO KIOJTAKA...
Finally, transwell assays were used to detect the influence of transfection of miRNA-885-5p mimic or miRNA-885-5p inhibitor on hepatoblastoma metastasis and invasion. The expression of miRNA-885-5p in liver tissue was higher than that in hepatoblastoma tissue (P < 0.05), and the relative ...