结论术前基于临床指标联合多序列MRI影像组学的综合模型可以无创而有效地预测HCC的GPC3阳性表达。 关键词: 肝细胞癌;磷脂酰肌醇蛋白聚糖3;钆塞酸二钠;磁共振成像;影像组学 ABSTRACT ObjectiveTo investigate the radiomics prediction of Glypican-3 (GPC3) positive expression in hepatocellular carcinoma (HCC) based on...
However, the diagnosis of HCC should not rely entirely on positive GPC3 immunostaining because focal immunoreactivity can be detected in a small subset of cirrhotic nodules. In addition, GPC3 expression in HCC can also be focal, and thus, the lack of ...
Loss-of-function mutations of GPC3 result in the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and Gpc-3 null mice display developmental overgrowth (PMID: 8589713; 18477453). In hepatocellular carcinoma (HCC), the overexpression of glypican 3 has been demonstrated to be a reliable diagnostic ...
Loss-of-function mutations of GPC3 result in the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and Gpc-3 null mice display developmental overgrowth (PMID: 8589713; 18477453). In hepatocellular carcinoma (HCC), the overexpression of glypican 3 has been demonstrated to be a reliable diagnostic ...
结论:无论在蛋白质水平还是在mRNA水平,GPC3在HCC的早期诊断中 均具有良好的敏感性和特异性,有望成为新的肝癌早期诊断标志物。肝穿刺活 检组织GPC3染色是一个有效的肝癌早期病理诊断及鉴别诊断的辅助工具。 关键词:癌肝细胞磷脂酰肌醇蛋白聚糖3诊断免疫组织化学RT-PCR ...
General Information Expression alteration of glypican-3 (GPC3) is associated with several malignancies and has been identified as an overexpressed gene in hepatocellular carcinoma (HCC). Glypican-3 is a cell surface proteoglycan that bears heparan sulfate. It may be involved in the suppression/...
positive ratesofGPC-3inHCCserumwas significantlyhigher thanthatnormal controland hepatitis or hepaticcirrhosis(p<O.05).Theexpression ofGPC一3in theHCCsenlmwere significantly correlatedwiththeclinical parameters,such astheclinical stage,thepresence
GPC3-positive HepG2-Red-FLuc HCC cells expressingLuciferasewere purchased from PerkinElmer (RRID:CVCL5I98, Bioware, cat. no. BW134280) and were maintained as previously described33. Cells were cultured in a monolayer at 37 °C in Dulbecco’s modified Eagle Medium (DMEM; Gibco) supplemented wi...
(redirected fromglypican-3) GPC3 A gene on chromosome Xq26.1 that encodes glypican 3, a cell surface proteoglycan with heparan sulfate that inhibits the dipeptidyl peptidase activity of DPP4. It may be involved in modulating growth of mesodermal tissues, in IGF2-receptor interactions, and in cellu...
5 Since it shows high expression in HCC, GPC3 has a potential as a promising target for tumour-specific therapy. Also, because small amounts of GPC3 can be detected in the blood of some patients with GPC3-positive cancers,6, 7 measurement of GPC3 in the blood may be a useful diagnostic...