α-L-Fucosidases (EC 3.2.1.51), the only members of glycoside hydrolase family 29, are involved in many biological processes like inflammation, growth regulation, receptor interactions, and antigenicity. Their
Figure 1. Sequence similarity networks for protein families discussed in the text. Panel (a) (Section ‘Glycoside hydrolase GH128 family’), glycoside hydrolase family GH128 [9•]. Reprinted with permission from Nature Chemical Biology. Panel (b) (Section ‘Diheme peroxidases’), diheme cytoch...
This article contains supplemental Figs. S1 and S2. 1 Both authors contributed equally to this work. 3 The abbreviations used are: GH18 glycoside hydrolase family 18 pNP 4-nitrophenolate ITC isothermal titration calorimetry MU methylumbelliferyl PDB Protein Data Bank. ...
www.nature.com/scientificreports OPEN A metagenome-derived thermostable β-glucanase with an unusual module architecture Received: 31 August 2017 Accepted: 16 November 2017 Published: xx xx xxxx which defines the new glycoside hydrolase family GH148 Angel Angelov1, Vu Thuy Trang Pham1, Maria Übe...
et al. Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space. Proc. Natl Acad. Sci. USA 116, 6063–6068 (2019). Article CAS PubMed PubMed Central Google Scholar Ishida, T. et al. Crystal structure of glycoside hydrolase family 55 β...
Most α-amylases have been classified in glycoside hydrolase family 13 with a typical (β/α)8-barrel containing two aspartic acid and one glutamic acid residue that play an essential role in catalysis. An atypical α-amylase (BmaN1) with only two of the three invariant catalytic residues ...
Yanhong Liu1, Jigang Yu1, Fudong Li2, Hui Peng1, Xuecheng Zhang1,Yazhong Xiao1 & Chao He1 Subfamily 37 of the glycoside hydrolase family GH13 was recently established on the basis of the discovery of a novel α-amylase, designated AmyP, from a marine metagenomic library...
Gerwig1, Stéphane Duboux2, Christina Vafiadi2, Tjaard Pijning3 & Lubbert Dijkhuizen1 Lactic acid bacteria possess a diversity of glucansucrase (GS) enzymes that belong to glycoside hydrolase family 70 (GH70) and convert sucrose into α-glucan polysaccharides with (α1 → 2...
Glycoside Hydrolase family 30 (GH30) is a diverse family that contains various catalytic functions and has so far been divided into ten subfamilies (GH30_1-10). In this study, a GH30 phylogenetic tree using over 150 amino acid sequences was contructed. The members of GH30 cluster into ...
Briefly, the GeneHunt approach provides a Pfam-based domain-specific annotation of protein sequences2. More precisely, GeneHunt uses sequential HMM-profile searches28 to rapidly identify the detailed multi-domain organization of proteins containing a domain of interest (e.g., PF00150 for GH5). Fi...