Glycoprotein endo-alpha-1,2-mannosidasedoi:10.1007/978-3-642-58948-5_72No Abstract available for this chapter.Dietmar SchomburgUniversität zu KölnDrte StephanGBF — Gesellschaft für Biotechnologische Forschung mbHSpringer Berlin Heidelberg
Homo sapiens partial mRNA for glycoprotein endo-alpha-1,2-mannosidase (endo-alpha-1,2-mannosidase gene) The hexapeptide Arg-Asn-Gly-epoxyethylglycine-Ala-Val-OMe specifically inactivates membrane-bound N-glycosyltransferases. The specificity is demonstrated b......
Extensive mannose trimming of nascent glycoprotein N-glycans signals their targeting to endoplasmic reticulum-associated degradation (ERAD). ER mannosidase I (ERManI) and the EDEM protein family participate in this process. However, whether the EDEMs are
Endo-alpha-D-mannosidase is an enzyme involved in N-linked oligosaccharide processing which through its capacity to cleave the internal linkage between the glucose-substituted mannose and the remainder of the polymannose carbohydrate unit can provide an alternate pathway for achieving deglucosylation and...
E2E1-I53-50A contained elevated levels of oligomannose at positions 430, 448, 476, and 623 possibly reflecting steric occlusion of these sites to mannosidase because of the trimeric organization of E2E1. Four out of the five glycans on E1 were fully occupied with predominantly complex-type ...
ER degradation-enhanced α-1,2-mannosidase protein Endo H/T: ENGase H/T ENGase: Endo-β-N-acetylglucosaminidase ER: Endoplasmatic ERAD: ER-associated degradation ERT: Enzyme replacement therapy Fringe: Human β-1,3-N-acetylglucosaminyltransferase ...
There is increasing evidence for a role of this ER alpha1 ,2-mannosidase and for an enzymatically inactive alpha1,2-mannosidase homolog in ER quality control leading to the degradation of misfolded glycoproteins by the proteasome.A. Herscovics...
No endoplasmic reticulum Man9-alpha 1,2-mannosidase activity was detected in S. pombe, thus identifying Man9GlcNAc as the minimum precursor for oligosaccharide elongation in contrast to the Man8GlcNAc2 intermediate identified in S. cerevisiae (Byrd, J. C., Tarentino, A. L., Maley, F., ...
(2001). Structure and function of Class I alpha 1,2- mannosidases involved in glycoprotein synthesis and endoplasmic reticulum quality control. Biochimie 83: 757-762.A. Herscovics, Structure and function of class I a 1,2-mannosi- dases involved in glycoprotein synthesis and endoplasmatic ...
Alpha-mannosidase and beta-mannosidase from hen oviduct Thymidylate synthase (TS) catalyzes the folate-dependent methylation of deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP). We have i... T Sukeno,AL Tarentino,TH Bpummer,... - 《Colowick Sidney P Methods in Enzymology...