Interestingly, cancer cells behave as metabolic parasites, owing to the fact that they procure nutrients from the host cells via activating several catabolic processes, among which aerobic glycolysis is most common [15,16]. Sustained aerobic glycolysis has also been associated with the activation of ...
A longer progression-free survival is correlated with the POLE ultra-mutation, which also has the best prognosis [6]. By using this new classification system, patients can receive more personalized care [7]. The factors that influence OC development are not clear. One study found that an ...
Glycolysis, as one of the most conserved and best characterized pathways, was studied to evaluate its evolutionary conservation. The flux controlling step in glycolysis was found to vary over the tree of life. Further, phylogenetic analysis suggested at least 60 events of gene duplication and ...
The association of organelles has previously been observed and is often postulated to aid metabolic pathways that span organelles, such as photorespiration and nitrogen assimilation, and may also be beneficial for biochemical efficiency15,16,17,18. In addition to the clear metabolic intimacy of the o...
Methyl methacrylate (MMA) is a key precursor of polymethyl methacrylate, extensively used as a transparent thermoplastic in various industries. Conventional MMA production poses health and environmental risks; hence, citramalate serves as an alternative bacterial compound precursor for MMA production. The ...
as selection criteria in pivotal clinical trials for systemic combination therapies4,5. Anti-PD-1 monotherapy has been demonstrated with a well-tolerated safety profile and moderate antitumor activity for aHCC6,7. Nivolumab, an immunoglobulin (IG) G4 monoclonal antibody to PD-1, is the only ...
Glycolysis, as one of the most conserved and best characterized pathways, was studied to evaluate its evolutionary conservation. The flux controlling step in glycolysis was found to vary over the tree of life. Further, phylogenetic analysis suggested at least 60 events of gene duplication and ...
e Quantification of tumor incidence as measured by the number of tumors greater than or equal to 1.0 mm. The number of mice in each group is indicated. *p < 0.05 versus HK2 F/F, by Student’s t-test Full size image The effect of HK2 depletion on tumorigenesis and metabolism ...
Although none of the treatments induced genetic instability or enhanced mutagenesis, mutations in Ezh2 and Hras were enriched in X10/IGF1 treatment tumors. Conclusions Overall, these data suggest that the decreased mammary gland tumor latency time caused by chronic IGF1R activation is related to ...
How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs are exceptional among proliferating B and T cells, as they actively oxidize fatty acids (...