Glycolysis occurs in both aerobic and anaerobic states. In aerobic conditions, pyruvate enters the citric acid cycle and undergoes oxidative phosphorylation leading to the net production of 32 ATP molecules. In anaerobic conditions, pyruvate converts to lactate through anaerobic glycolysis. Anaerobic respi...
Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide adenylyl trans
The paper shows that a band-path filter plays an important role in the Fourier transformation of the one-shot input-output data, and the optimal pre-filter, which well approximates the performance index to the original performance index, can be easily calculated in the frequency domain. Finally...
input: glucose 2 ATP 4 ADP 2 NAD+ glycolysis output: 2 pyruvic acids 2 ADP 2 ATP 2 NADH pre kreb input: 2 pyruvic acids 2 CoA 2 NAD+ pre kreb output: 2 acetyl CoA 2 NADH 2 CoA 2 CO2 glucose carbons always come from... krebs...
Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic reprograming during therapeutic resistance development is under-studied. Here, through high-throughput stimulated Raman scattering imaging and single cell analysis, we
PGK1-323 K acetylation enhances PGK1's catalytic function, leading to increased glucose metabolism, ATP production and lactate output. Furthermore, PGK1 acetylation was found to bolster cell proliferation and metastasis, as indicated by improved cell viability, cell cycle progression, clonality, wound...
{R} g\)are obvious for the determination of the feasibility of single reactions and reaction pathways. However, the output of such an approach is a binary statement whether a certain reaction is thermodynamically feasible or not. It would also be interesting to know how fast a reaction is if...
Altered aerobic glycolysis is a well-recognized characteristic of cancer cell energy metabolism, known as the Warburg effect. Even in the presence of abundant oxygen, a majority of tumor cells produce substantial amounts of energy through a high glycolytic metabolism, and breast cancer (BC) is no...
Pre-ranked gene lists and Hallmark pathway gene sets (mh.all.v2022.1.Mm.symbols.gmt) were used as the input for the fgsea function in the fgsea R package (v.1.22.0) to perform the GSEA44. scRNA-seq methodology Tumor preparation Tumors were dissected into small pieces and re-suspended ...