Full size image SHP1, PKM2 and LDHB associate with each other and P5C inhibit T cell glycolysis We also captured PKM2 from Jurkat cells, and checked all the associated proteins by LC/MS-MS. Using GO term analysis, we uncovered that the proteins bound to PKM2 participate in ATP metabolism ...
Glycolysis occurs in: (a) bacteria (b) animals (c) plants What is the equation for anaerobic cellular respiration? Glycolysis doesn't need oxygen to produce ATP and neither does fermentation which means without oxygen the body is still able to produce ATP. So by that, can an organism still...
Where does glycolysis take place and can it take place with or without oxygen?Glycolysis:Glycolysis is defined as a multi-step process that involves ten enzymes in order to breakdown the sugar (glucose) into pyruvate. This process is responsible for the release of energy in th...
Full size image We next sought to explore the signaling pathways by which B7-H3 mediated the expression of HK2. Previous studies have shown that the expression of HK2 could be regulated by STAT3 in tumor cells such as MCF7, HepG2, and A549 cells24,25. In addition, STAT3 signaling is ...
Full size image We formulated a stoichiometric model that describes glucose–xylose co-metabolism under the studied conditions (Fig. 2; Additional file 1), and we performed the flux analysis using the specific accumulation rates calculated as the output of the kinetic model based on the cultivation...
Download: Download full-size image Figure 1. p300 Catalyzes Histone Khib (A) p300 deficiency impairs both Khib and Kac of histones in cells. Histone Khib and Kac levels were analyzed in WT and p300 KO HCT116 cells by immuno-blotting with the indicated antibodies. (B) Overexpression of WT ...
Full size image FZA regulated aerobic glycolysis through the PI3K/Akt-mTOR pathway Based on the results of proteomics, metabolomics and network pharmacology experiments, we speculated that FZA played an anti-NSCLC role by regulating tumor energy metabolism. To verify the hypothesis, the glucose and ...
Full size image As a multifactorial disorder, schizophrenia is likely to be a consequence of several molecular differences of small effect [22] triggered by environmental factors [23]. These subtle and sometimes even non-significant molecular differences may be one of the reasons why it has been ...
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Full size image Step 2: Activity-based TFA with accounting for the medium influence on metabolite activity coefficientsIn step 2, the presence of all metabolites involved in the glycolysis pathway is considered for the prediction of\(Q_{\gamma }\). Therefore, the maximum concentration of the me...