Structure/function studies have provided exquisite insights defining features responsible for lipid headgroup selectivity and hydrophobic 'pocket' adaptability for accommodating hydrocarbon chains of differing length and unsaturation. In humans, evolutionarily-modified GLTP-folds have been identified with altered...
adipocytes within subcutaneous adipose tissues and found that, compared to the healthy individuals, a total of 23 proteins specifically expressed were identified in obese subjects, which are mainly involved in glucose and lipid metabolism, energy regulation, cytoskeleton structure and redox reactions [102...
Structure-function features of a Mycoplasma glycolipid synthase derived from structural data integration, molecular simulations, and mutational analysis. PLoS One 8, e81990 (2013). Article ADS PubMed PubMed Central Google Scholar Andrés, E., Martínez, N. & Planas, A. Glycolipid biosynthesis in...
aFor our studies, the jejunum part of the mouse intestine was used as a model system. Schematic overview of the functional structure and features of the intestinal epithelium and of enterocytes.bGalectin expression profile in the jejunum. MS results of galectins that were purified from jejunum ce...
Lactate dehydrogenases: structure and function. Adv Enzymol Relat Areas Mol Biol. 1973;37:61–133. CAS PubMed Google Scholar Cui XG, Han ZT, He SH, Wu XD, Chen TR, Shao CH, et al. HIF1/2 alpha mediates hypoxia-induced LDHA expression in human pancreatic cancer cells. Oncotarget. ...
Nature and Science of Sleep Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH The Impact of Glycolipid Metabolic Disorders on Severity Stage-Specific Variation of Cardiac Autonomic Function in Obstructive Sleep Apnea: A Data-Driven Clinical Study ...
As the name suggests,glycolipidsarelipidscontaining sugar moieties. They make an essential part of cell membranes and are particularly found in the outer leaflet of the bilayer.Glycolipidsare involved in various important functions like cell–cell recognition andtissue immunity. The basic structure of ...
Again, detailed information on structure-function relationship is not yet available. ATP-binding cassette transporters (ABC transporters) provide the focus of this review. They play pivotal roles in the assembly of many bacterial surface glycoconjugates belonging to different organizational types and their...
and have been investigated for the correlation between the structure and activity thereof; it has been demonstrated that α-GalCer (compound a), developed by Kirin Brewery Co., Ltd., out of the series of synthetic analogues, exhibits the highest activity, and that the corresponding β-form (β...
Therefore, in such a disease condition, if a drug treatment suppressing the function of NKT cells could be established, this would lead to not only the prevention and treatment of autoimmune diseases, but also the treatment of allergic diseases. However, no effective drug has yet been known to...