The latter may then enter the glycolytic pathway, but if glucose-6-phosphatase is present, free glucose can be formed. Show moreView chapterExplore book Carbohydrate Metabolism I N.V. Bhagavan, Chung-Eun Ha, in Essentials of Medical Biochemistry, 2011 Alternative Substrates of Glycolysis The ...
is a regulator of glycogenolysis rate. All these facts suggest that the metabolic regulation of the two pools must be different and that the MG pool is a more stable form than the PG pool. On the other hand, the greater fraction of human muscle MG than PG is utilized in a marathon ...
A cross-link with apoptosis is addressed. All these genes could be analyzed in GSD patients with unusual discrepancies between genotype and phenotype in order to discover genetic variants potentially modifying their phenotype. The discovery of modifier genes related to glycogen-selective autophagy and ...
Hepatic glycogen phosphorylase activity was measured using a colorimetric Glycogen Phosphorylase Assay Kit (ab273271, Abcam, Waltham, MA, USA) that measures the appearance of G1P when excess substrate is present. To measure glycogen phosphorylase activity, liver samples (50 mg) were homogenized in th...
Familial hypercholesterolemia is an autosomal dominant disease that is caused by the deficiency of the LDL receptor on the surface of cells in the liver and other organs. As a result, cholesterol is not moved into the cells. Under normal conditions, when enough cholesterol is present in the cel...
and synthesis of efas. Gluconeogenesis is uniquely dominant over glycolysis under all surveyed circumstances, whilst the TCA pattern represents an eclectic mixture of standard and unusual enzymes. The recognition of old-fashioned anaerobic enzymes reflects the ability of this protist to endure in low-ox...
Proteins in the body undergo continual breakdown and synthesis. Insulin is a polypeptide hormone that stimulates fat and muscle to take up glucose. Once released from the pancreas, it has a first-order half-life in the blood of 8.0 min....
Eleven GSD Ia participants (M: 6, F: 5) were enrolled in the study (mean age: 21.6 ± 4.3 years). All participants exhibited body mass index > 25 kg/m2 (mean: 28.2 ± 3.6 kg/m2). The clinical profile of the participants is summarized in Table 1. At baseline, four...
The regulation of sleep, although not totally understood, can be considered as the interaction between circadian clock and homeostatic mechanisms (Borbely and Achermann1999). The molecular components (i.e. proteins) of circadian clock are present in each cell where their cyclic expressions are regulat...
In all investigated cell lines, T-1686568 provided a similar robust activity, with the ED50 ranging 4 to 7 μM (Fig. 3a). This observation indi- cates that GSK3β phosphotransferase activity is needed for SARS-CoV-2 infection, independent of host cell type. While these results ...