Delayed heart rate recovery after exercise as a risk factor of incident type 2 diabetes mellitus after adjusting for glycometabolic parameters in men. Int J Cardiol. 2016;221:17-22.Yu, T. Y. et al. Delayed heart rate recovery after exercise as a risk factor of incident type 2 diabetes ...
A dataset containing 1,386,844 tandem mass spectra acquired by stepped collision energy HCD (sceHCD) fragmentation for intact glycopeptides from five mouse tissues9(brain, heart, kidney, liver, and lung) was used for the performance evaluation. From the 1,282,263 oxonium ion-containing glycopept...
In the last decades, an interesting approach that emerges and remains as a very challenging task for the development of new drugs, is the design and synthesis of glycomimetics. A glycomimetic is defined as chemical entities that mimic the structure or function of a native carbohydrate. This new...
No mouse had cerebral damage, except for one animal in the control group that presented inflammatory infiltrate. Table 5: Histopathologic injuries in organs of animals that survived from experimental sepsis. Control Group Day Liver Kidney Intestines Lungs Heart Brain 1 Intense Congestion Intense ...
Table 2 Enzymes in glycolysis for possible PDAC therapy Full size table Recently, the fructo-1,6-bisphosphatase (FBP)-mediated rate-limiting step in gluconeogenesis has been reported to inhibit the Warburg effect andKRASsignaling. Furthermore, FBP-2 and FBP-1 were found to attenuate soft tissue...
To address this gap, we describe a generalizable workflow for the efficient production of structurally diverse GTs using standardE. coliexpression strains. At the heart of this workflow is a protein engineering method called SIMPLEx (solubilization of IMPs with high levels of expression)32that enables...
Global proteome profiling of the cell lines using isobaric tags for relative and absolute quantitation (iTRAQ) labeling and two- dimensional (2D) liquid chromatography-tandem MS (LC-MS/MS) led to the quantification of 8063 proteins. To analyze the glycoproteins, glycosite-containing peptides were ...
The evidence that ETS increases risk of death from heart disease is similar to that which existed in 1986 when the US Surgeon General concluded that ETS ca... SA Glantz,WW Parmley - 《Circulation》 被引量: 1556发表: 1991年 Secondhand smoke as an acute threat for the cardiovascular system:...
Our data reveal, for the first time, a dramatic effect of the gene polymorphism on the glycosylation pattern of fetuin, which needs to be considered when fetuin would be used as a biomarker. Based on this knowledge we can obtain and annotate the full proteoform profiles of fetuin from 20 ...
For binding analysis, 93.97 μM Stx1B was injected over the sensor surface for 1 min. For affinity analysis, Stx1B, at the following concentrations: 4.16, 8.31, 16.62 (repeated twice), 33.25, 66.5 μM, was injected for 1 min at the flow rate 50 μl/min and the dissociation was ...