Glycerol-3-phosphate dehydrogenaseGlpAArchaeaGlycerol metabolismNADH oxidaseMolybdopterin oxidoreductaseOperonComplexGlycerol-3-phosphate (G3P) is a key intermediate of glycerol metabolism and is oxidized to di
Glycerol-3-phosphatedehydrogenase, from the glycerol phosphate shuttle • Fatty acyl–CoA dehydrogenase, from the first step in β-oxidation of fatty acids Coenzyme Q Coenzyme Q, a lipid-soluble quinone (Fig. 7-3), also known asubiquinone, accepts electrons from FMNH2in complex I and FADH2in...
Inhibition by FFAs is more complex in that oleate inhibited oxidoreductase activity, which transfers electrons from GPD2 to CoQ, but not dehydrogenase activity, which oxidizes G3P in a non-competitive and BSA-relievable way65. Other studies have shown that the inhibitory effects of FFAs might ...
Besides Gro3P and 2-PG, PGP/G3PP has also been shown to detoxify certain toxic glycolytic side products in cancer cell lines, particularly 4-phosphoerythronate and 2-phospholactate, pro- duced by glyceraldehyde 3-phosphate dehydrogenase and pyr- uvate kinase, respectively8,56. Upon their ...
such as glucose transporter 4, hexokinase, glycerol-3-phosphate dehydrogenase and lipase contents between fat tissues that play a critical role in active lipolysis. Epididymal fat exhibited higher lipolytic activity than inguinal fat because of higher lipase and glucose metabolism-related protein contents...
Batke J, Asbóth G, Lakatos S, Schmitt B, Cohen R (1980) Substrate-induced dissociation of glycerol-3-phosphate dehydrogenase and its complex formation with fructose-bisphosphate aldolase. Eur J Biochem 107:389–394 View ArticleBatke, J., Asboth, G., Lakatos, S., Schmitt, B. and Cohen,...
Certain pathogenic trypanosomatids are highly dependent on glycolysis for ATP production, and hence their glycolytic enzymes, including glycerol-3-phosphate dehydrogenase (GPDH), are considered attractive drug targets. The ternary complex structure of Leishmania mexicana GPDH ( LmGPDH) with dihydroxyacetone...
Nucleotide sequence of the glycerol- 3-phosphate dehydrogenase gene of Escherichia coli and regu- lation by cAMP-CRP complex. Agric. Biol. Chem. 53:1135- 1143.Choi, Y.-L., S. Kawase, M. Kawamukai, R. Utsumi, H. Sakai, and T. Komano. 1989. Nucleotide sequence of the glycerol-3- ...
Glycerol-3-phosphate dehydrogenaseGlpAArchaeaGlycerol metabolismNADH oxidaseMolybdopterin oxidoreductaseOperonComplexGlycerol-3-phosphate (G3P) is a key intermediate of glycerol metabolism and is oxidized to dihydroxyacetone phosphate aerobically or anaerobically by appropriate G3P dehydrogenases. A ...
Glycerol 3-phosphate dehydrogenase (mGPDH) is one of the enzymes that have the above ability [12], and several studies have reported the role of mGPDH as a potent superoxide generator [12, 13]. However, no published information is available about the superoxide production associated with mG...