Glycerin is used as a plasticizer of gelatin in the production of soft-gelatin capsules and gelatin suppositories. Glycerin is employed as a therapeutic agent in a variety of clinical applications, and is also
cardiac, renal, or liver disease and/or diabetes mellitus may be exacerbated by shifts in body water as a result of oral, intravenous, or rectal (suppositories) administration of glycerol. No systemic effects have been reported following the application of large amounts of glycerol to the skin....